Summary
Two pingueculae combined with pterygia were studied by light and electron microscopy. Hyaline degeneration of the collagen, dark staining granular, von Kossa negative concretions and elastotic material were observed in both conditions together with marked changes in the fibroblasts, endothelial cells, pericytes and the basement membrane of conjunctival capillaries and small veins. The elastotic material is similar to that observed in solar elastosis, where the collagen fibers are less severely damaged. Chronic sun exposure of the pericorneal conjunctiva may damage endothelial cells primarily and disturb vascular exchanges. This would result in accelerated degeneration and regeneration of endothelial cells, in thickening of the basement membrane and, secondarily, disturbed metabolism of fibroblasts with alterations of the collagen and elastic fibers.
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Ansari, M.W., Rahi, A.H.S., Shukla, B.R.: Pseudoelastic nature of pterygium. Brit. J. Ophthal. 56, 473–476 (1970)
Berhelon, S., Ledoux-Corbusier, M., Panis, P.: La pinguecula; ses rapports avec les atteintes du tissu élastique cutané (autofluorescence et action de l'élastase). Bull. Soc. Belge Ophtal. 149, 449–461 (1968)
Bodley, H.D., Wood, R.L.: Ultrastructural studies on elastic fibers using enzymatic digestion of thin sections. Anat. Rec. 112, 71–88 (1972)
Braun-Falco, O.: A propos de la nature de l'élastose sénile-actinique. In: Maladies du tissu élastique cutané, p. 389. Paris: Masson 1968
Braun-Falco, O.: Die Morphogenese der senil-aktinischen Elastose. Eine elektronenmikroskopische Untersuchung. Arch. klin. exp. Dermatol. 235, 138–160 (1969)
Cardenas-Ramirez, L., Zaragoza de C, A.M. Histopathologic changes in the evolution of pterygium. Patologia 14, 35–49 (1976)
Cogan, D.G., Kuwabara, T., Howard, J. The nonelastic nature of pinguecula. Arch. Ophthal. 61, 388–389 (1959)
Comings, D.E., Okada, F.A.: Electron microscopy of human fibroblasts in tissue culture during logarithmic and confluent stages of growth. Exp. Cell. Res. 61, 295–301 (1970)
Conrads, H.: Beitrag zur Histologie der Pinguecula bei bandformiger Hauthorndegeneration. Ophtalmologica 134, 97–99 (1957)
Danielsen, L., Kobayasi, T.: Degeneration of dermal elastic fibers in relation to age and light-exposure. Preliminary report on electron microscopic studies. Acta Dermatol. Vener. 52, 1–10 (1972)
Fuchs, E.: Zur Anatomie der Pinguecula. Arch. Ophthal. 37, 143–191 (1891)
Fuchs, E.: über das Pterygium. Arch. Ophthal. 38, 1–90 (1892)
Ghadially, F.N.: Waxing and waning of nuclear fibrous lamina. Arch. Pathol. 94, 303–307 (1972)
Ghadially, F.N.: Nuclear fibrous lamina in pathological human synovial membrane. Virchows Arch. Abt. B Zellpath. 15, 223–228 (1974)
Hogan, M.J., Alvarado, J.: Pterygium and pinguecula: electron microscopic study. Arch. Opthal. 78, 174–186 (1967)
Lipetz, J., Cristofalo, V.J.: Ultrastructural changes accompanying the aging of human diploid cells in culture. J. Ultrastruct. Res. 39, 45–56 (1972)
Mitchell, R.E.: Chronic solar dermatosis: a light and electron microscopic study of the dermis. J. Invest. Dermatol. 48, 203 (1967)
Nakamura, K., Johnson, W.C.: Ultraviolet light induced connective tissue changes in rat skin: a histopathologic and histochemical study. J. Invest. Dermatol. 51, 253 (1968)
Niebauer, G., Stockinger, L.: über die senile Elastosis. Arch. klin. exp. Dermatol. 221, 122–143 (1965)
Pierard, J., Kint, A., de Bersaques, J.: L'élastose sénile in: Maladies du tissu élastique cutané, p. 373. Paris: Masson 1968
Regnault, F., Kern, P.: Age related changes of capillary basement membrane. Pathol. Biol. 22, 737–739 (1974)
Ringvold, A.: The ultrastructure of the extracellular components of the limbal conjunctiva in the human eye. Acta Ophthal. 50, 343–404 (1972)
Roy, S.: Ultrastructure of articular cartilage in experimental hemarthrosis. Arch. Pathol. 86, 69–76 (1968)
Sams, W.M., Jr., Smith, J.G., Jr., Buck, P.C.: The experimental production of elastosis with ultraviolet light. J. Invest. Dermatol. 43, 467–471 (1964)
Snodgress, A.B., Dorsey, C.H., Bailey, G.W.H., Dickson, L.G.: Conventional histopathologic staining methods compatible with Epon-embedded, osmicated tissue. Lab. Invest. 26, 329–337 (1972)
Vass, Z., Tapaszto, I.: The histochemical examination of the fibers of pterygium by elastase. Acta Ophthal. 42, 849–854 (1964)
Vracko, R., Benditt, E.P.: Capillary basal lamina thickening: its relationship to endothelial cell death and replacement. J. Cell. Biol. 47, 281–284 (1970)
Vracko, R.: Basal lamina layering in diabetes mellitus: evidence for accelerated rate of cell death and cell regeneration. Diabetes 23, 94–104 (1974)s
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Lemercier, G., Cornand, G. & Burckhart, MF. Pinguecula et pterygion: étude histopathologique et ultrastructurale. Virchows Arch. A Path. Anat. and Histol. 379, 321–333 (1978). https://doi.org/10.1007/BF00464475
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DOI: https://doi.org/10.1007/BF00464475