Untersuchungen zum Generations-cyclus maligner Tumoren im HNO-Bereich und ihre Bedeutung für die cytostatische Therapie
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Investigations on cell generation cycle of malignant oto-rhino-laryngo-logical tumors and their evidence for cytostatic therapy
More than 40 patients with malignant tumors of head and neck were investigated on cytostatic therapy. In these patients advances tumor stage was manifested. Therefore a major curative effect of therapy was not expected. In the beginning of cytostatis surgical and radiological possibilities were exhausted.
Theoretical basis of the performed therapy were animal experiments of H. O. Klein in which evidence of cell cinetics for cytostatic therapy was demonstrated. The tumorcell cycle was determined autoradiographically with the double labeling method (H3- and C14-Thymidine) in vitro in most of the patients.
A slow proliferation rate of tumor cells regularly was found. So a high dose oytostatic treatment (high dose monodrug therapy) appeared not to be optimal. Therefore we prefered in our cases a combination therapy with Cyclophosphamide (2–3 mg/kg body weight/day) and Methotrexate® (2.5–5 mg/day). Methotrexate® was given on only 3 days of the week to avoid severe haematological complications. In other cases without these complications the substance was administered dayly. In drug incompatibility other oytostatic substances were used.
In most of the patients tumor development could be retarded, stopped, or a regression could be induced. Only in some cases no effect was observed. Details of cytostatic therapy, evaluation of toxic side effects and complications, also time and success of therapy are demonstrated in diapositives.