Die Bedeutung des Immun-globulins E bei der Differentialdiagnose der Rhinopathia vasomotorica
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The significance of ige in the diagnosis of vasomotor rhinitis
IgE, an immunglobulin with the antibody properties identical with reagins, is usually markedly elevated in immediate-type allergic disorders. In 94 patients with allergic and non-allergic vasomotor rhinitis, the IgE concentrations in serum and nasal secretions were assayed to determin wether or not the IgE levels could give any conclusive evidence as to the etiology of these types of rhinitis. IgE-concentrations were measured by radioimmunsorbent-test (RIST).
In all of the studied groups the serum IgE-concentration were higher than the levels in nasal secretions. The mean concentrations in vasomotor rhinitis (IgE in serum: 75U/ml; secretions: 30.9 U/ml) were significantly lower than the corresponding concentrations of patients with perennial allergic rhinitis (serum: 219.5 U/ml; secretions: 57 U/ml) and patients with hay fever (serum: 301 U/ml; secretions: 100 U/ml). The difference in concentration of all three groups were significant, however it was not possible to determine the diagnosis for the individual case solely by the IgE-concentrations, because the normal range of IgE levels was very wide. Five patients showed higher IgE-concentrations in nasal secretions than in the serum. This finding indicates that IgE is probably also sythesized locally in the nasal mucosa.