Since the salivary glands are rich of norepinephrine, cyclic AMP as second messenger of β-adrenergic function was determined in the parotid saliva of patients with arterial hypertension. The cAMP was determined in correlation to the flow rate by the radio-isotope dilution test of Gilman. The corresponding plasma renin activity was determined by radioimmunoassay. In patients with normal renin hypertension and with high renin hyper-tension an increase of the cAMP concentration up to six times the normal range could be observed, while in low renin hypertension the values were similar to those of a normal control group. The increased secretion of cAMP could be inhibited by propanolol. The conclusion is, therefore, that the β-adrenergic system is activated in normal and high renin hypertension.
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Schmid, G., Heidland, A. & Wigand, M.E. Cyclisches AMP im menschlichen Parotisspeichel bei arterieller Hypertonie und unterschiedlicher Plasma-Renin-Aktivität. Arch Otorhinolaryngol 210, 258 (1975). https://doi.org/10.1007/BF00460019