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Cyclisches AMP im menschlichen Parotisspeichel bei arterieller Hypertonie und unterschiedlicher Plasma-Renin-Aktivität

Cyclic amp of parotid saliva in patients with arterial hypertension and different plasma renin activity

Summary

Since the salivary glands are rich of norepinephrine, cyclic AMP as second messenger of β-adrenergic function was determined in the parotid saliva of patients with arterial hypertension. The cAMP was determined in correlation to the flow rate by the radio-isotope dilution test of Gilman. The corresponding plasma renin activity was determined by radioimmunoassay. In patients with normal renin hypertension and with high renin hyper-tension an increase of the cAMP concentration up to six times the normal range could be observed, while in low renin hypertension the values were similar to those of a normal control group. The increased secretion of cAMP could be inhibited by propanolol. The conclusion is, therefore, that the β-adrenergic system is activated in normal and high renin hypertension.

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Schmid, G., Heidland, A. & Wigand, M.E. Cyclisches AMP im menschlichen Parotisspeichel bei arterieller Hypertonie und unterschiedlicher Plasma-Renin-Aktivität. Arch Otorhinolaryngol 210, 258 (1975). https://doi.org/10.1007/BF00460019

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