Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Basic study of nasal provocative test first report: Side, site of the nose, size of site and allergen amount

  • 24 Accesses

  • 20 Citations

Summary

The methodology of the provocative nasal test has varied according to the investigators. In order to establish a standard method of this test quantification of the nasal challenge, including the amount of the allergen, nasal site, side and size of allergen deposition, was studied. From the results obtained it is preferable to use the end point test and to apply allergen to the anterior part of the inferior turbinate in a 7mm2 size of surface area, bilaterally. An alternative test is to use a fixed amount of allergen (500 μg house dust in house dust allergy).

This is a preview of subscription content, log in to check access.

References

  1. Aas, K.: Nasal eosinophilia in so-called bacterial hypersensitivity in asthmatic children. Acta Pediat. Scand. 50, 1–6 (1961)

  2. Asano, Y.: Clinical study on the etiologic factors of so-called nasal allergey (in Japanese). Jap. J. Otol. 70, 1723–1752 (1967)

  3. Ashan, G.: Drettner, B.: Nasal obstruction at provocation experiment in patients with hay-fever. Acta Otolaryng. Suppl. 140, 91–100 (1958)

  4. Bernstein, L., Safferman, R.: Clinical sensitivity to green algae demonstrated by nasal challenge and in vitro tests of immediate hypersensitivity. J. Allergy 51, 22–28 (1973)

  5. Collins-Williams, C, Nizami, R. M., Lamerza, C, Chiu, A. W.: Nasal provocative testing with molds in the diagnosis of perennial allergic rhinitis. Ann. Allergy 30, 557–561 (1972)

  6. Connell, J. T.: An instrument for measuring the effective cross sectional nasal air way. J. Allergy 37, 127–134 (1966)

  7. Connell, J. T.: Quantitative intranasal pollen challenges. J. Allergy 39, 358–367 (1967)

  8. Dean, L. W., Linton, L. D., Linton, S. S.: Intramucosal test for hypersensitivity in allergic rhinitis. Ann. Otol. Rhinol. Laryng. 44, 317–326 (1935)

  9. Feinberg, S. M., Stier, R. M., Grater, W. C.: A suggested quantitative evaluation of the degree of sensitivity of patients with ragweed pollinosis. J. Allergy 23, 387–394 (1952)

  10. Fontana, V. J., Indyk, L., Zanjamiman, M: Ragweed pollen challenge in a controled environment. J. Allergy 54, 235–243 (1974)

  11. Grobler, N. J., Orie, N. G., Devries, K.: Measurement of the reaction of the nasal mucosa in provocation tests. Allergie Asthma 12, 24–31 (1966)

  12. Halpern, S. R., Holman, L., Whittaker, Ch.: The correlation between skin and respiratory mucous membrane test with molds in allergic rhinitis. Ann. Allergy 19, 1407–1414 (1961)

  13. Harris, L. H.: Allergy to grain dusts and smuts. J. Allergy 10, 327–336 (1939)

  14. Harris, L. H.: Experimental reproduction of respiratory mold allergy. J. Allergy 12, 279–289 (1940)

  15. Hasegawa, M.: Determination of nasal airway resistance and its clinical application (in Japanese). Jap. J. Otol. 76, 656–678 (1973)

  16. Hosen, H.: Provocative nasal tests for diagnosis of inhalant allergens. Correlation with skin tests and clinical symptoms. Ann. Allergy 23, 497–505 (1965)

  17. McLean, J. A., Ciarkowski, A. A., Ch. E. M. S., Solomon, W. R., Mathew, K. P.: An improved technique for nasal inhalation challenge tests. J. Allergy 57, 153–163 (1967)

  18. Miyashita, H., Ishikawa, T., Fujita, Y., Shimada, T.: Clinical evaluation of nasal provocation test (in Japanese). Jap. J. Otol. 76, 1360–1367 (1973)

  19. Nauman, H. H., Naumann, W. H., Schubert, B.: Zur Methodik des Schleimhauttestes bei Nasenallergie. Z. Laryng. 48, 198–203 (1969)

  20. Okuda, M., Asano, Y.: The significance of skin reaction in nasal allergy and provocation test (in Japanese). Otolaryng. Tokyo 37, 31–38 (1965)

  21. Okuda, M. et al.: Nasal provocation test in nasal allergy by paper disc method (in Japanese). Otolaryng. Tokyo 43, 225–230 (1971)

  22. Okuda, M.: Fundamental and clinical studies on nasal allergy (in Japanese). Otol. Fukuoka 20, 297–344 (1974)

  23. Patterson, R.: Allergic diseases. Diagnosis and Management. Philadelphia-Toronto: J. B. Lippincott 1972

  24. Popa, V., Al-George, S.: Nasal provocative test in allergic perennial rhinitis. A preliminary study. Ann. Allergy 27, 45–53 (1969)

  25. Sherman, W. B.: Hypersensitivity. Mechanism and Management. Philadelphia-London-Toronto: W. B. Saunders 1968

  26. Shimada, T., Ishikawa, T., Fujita, Y., Miyashita, H.: The effect of hyposensitization therapy with dermatophagoides farinae extract to patients with nasal allergy (in Japanese). Jap. J. Otol. 76, 1405–1413 (1973)

  27. Taylor, G., Shivalkar, P. R.: Changes in nasal airways resistance on antigenic challenge in allergic rhinitis. Clinical Allergy 1, 63–73 (1971)

  28. Tuft, L., Torsney, P. J., Ettelson, L. N., Heck, K. M.: Ophthalmic and nasal mucosal tests as an aid in the determination of house dust allergy. J. Allergy 33, 448–457 (1962)

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Okuda, M. Basic study of nasal provocative test first report: Side, site of the nose, size of site and allergen amount. Arch Otorhinolaryngol 214, 241–246 (1977). https://doi.org/10.1007/BF00458318

Download citation

Key words

  • Nasal provocative test
  • Quantitative challenge
  • Different sensitivity of side and site