Archives of oto-rhino-laryngology

, Volume 241, Issue 1, pp 65–74 | Cite as

Tubuloreticular structures in laryngeal carcinoma

  • P. Schenk
Article
Received:
Accepted:

Summary

Tubuloreticular structures (TRS) were observed electron microscopically in stroma cells of human laryngeal carcinoma. The TRS appeared as networks of membranous tubules 20–30 nm in diameter, which were always situated in dilations of the endoplasmic reticulum (ER). The presence of TRS was observed not only in cells situated in the tumour stroma, but also in some stroma cells which had migrated to the carcinomatous epithelium. However, they were not found in malignant keratinocytes. In some places, incomplete forms of TRS may be observed, which in earlier reports have been referred to as worm-like or comma-shaped bodies. These incomplete forms of TRS, which are clearly shown to arise contiguous to the ER cisternae, may represent different developmental stages of TRS morphogenesis rather than disintegration steps. The observations indicate that the TRS — seen in various disorders such as viral, neoplastic, and auto-immune diseases — may well represent a common reaction pattern of the ER system of the host cell.

Key words

Tubuloreticular structures Endoplasmic reticulum Macrophages Laryngeal carcinoma 
This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Arnold W, Huth F (1979) Viren, virusähnliche und auf Viren hinweisende Strukturen beim Karzinom des Nasopharynx. Arch Otorhinolaryngol 222: 295–317Google Scholar
  2. 2.
    Baringer JR, Swoveland P (1972) Tubular aggregates in endoplasmic reticulum: evidence against their viral nature. J Ultrastruct Res 41: 270–276Google Scholar
  3. 3.
    Basset F, Escarc J, Le Crom M (1972) A cytoplasmic membranous complex in histiocytosis. X. Cancer 29: 1380–1386Google Scholar
  4. 4.
    Bassot JM (1966) Une forme microtubulaire et paracristalline de reticulum endoplasmique dans les photocytes des Annelides Polynoinae. J Cell Biol 31: 135–158Google Scholar
  5. 5.
    Bloodworth JMB, Shelp WD (1970) Endothelial cytoplasmic inclusions. Arch Pathol 90: 252–258Google Scholar
  6. 6.
    Caputo R, Alessi E, Allegra F (1981) Generalized eruptive histiocytoma. A clinical, histologic, and ultrastructural study. Arch Dermatol 117: 216–222Google Scholar
  7. 7.
    Chandra S (1968) Undulating tubules associated with endoplasmic reticulum in pathologic tissues. Lab Invest 18: 422–428Google Scholar
  8. 8.
    Chandra S, Stefani SS (1976) A possible mode of formation of tubuloreticular structures. J Ultrastruct Res 56: 304–311Google Scholar
  9. 9.
    Esau K, Gill RH (1971) Aggregation of endoplasmic reticulum and its relation to the nucleus in a differentiating sieve element. J Ultrastruct Res 34: 144–158Google Scholar
  10. 10.
    Esau K, Hoefert LL (1980) Endoplasmic reticulum and its relation to microtubules in sieve elements of sugarbeet and spinach. J Ultrastruct Res 71: 249–257Google Scholar
  11. 11.
    Ghadially FN (1982) Ultrastructural pathology of the cell and matrix, 2nd edn. Butterworths, London, pp 398–405Google Scholar
  12. 12.
    Gianotti F, Caputo R (1971) Skin ultrastructure in Letterer-Siwe disease treated with vinblastine. Mode of penetration of Langerhans granules into the nucleus. Br J Dermatol 84: 335–345Google Scholar
  13. 13.
    Grimley PM, Barry DW, Schaff Z (1973) Induction of tubular structures in the endoplasmic reticulum of human lymphoid cells by treatment with 5-bromo-2′-deoxyuridine. J Natl Cancer Inst 51: 1751–1760Google Scholar
  14. 14.
    Györkey F, Sinkovics JG, Györkey P (1971) Electron microscopic observations on structures resembling myxovirus in human sarcomas. Cancer 27: 1449–1454Google Scholar
  15. 15.
    Györkey F, Sinkovics JG, Min KW, Györkey P (1972) A morphologic study on the occurrence and distribution of structures resembling viral nucleocapsids in collagen diseases. Am J Med 53: 148–158Google Scholar
  16. 16.
    Hashimoto K, Chandler RW (1972) Paramyxovirus-like inclusions in systemic lupus erythematosus. Acta Derm Venereol (Stockh) 52: 263–277Google Scholar
  17. 17.
    Hashimoto K, Thompson DF (1970) Discoid lupus erythematosus. Electron microscopic studies of paramyxovirus-like structures. Arch Dermatol 101: 565–577Google Scholar
  18. 18.
    Hruban Z, Mochizuki Y, Morris HP, Slesers A (1972) Endoplasmic reticulum, lipid, and glycogen of Morris hepatomas. Lab Invest 26: 86–99Google Scholar
  19. 19.
    Hruban Z, Wong TW, Itabashi M, Lyon ES (1976) Glomiform and fibrillar cytoplasmic inclusions. Virchows Arch [Cell Pathol] 20: 91–102Google Scholar
  20. 20.
    Hulanicka B, Barry DW, Grimley PM (1977) Induction of tubuloreticular inclusions in human lymphoma cells (Raji line) related to S-phase treatment with halogenated pyrimidines. Cancer Res 37: 2105–2113Google Scholar
  21. 21.
    Jenson AB, Spjut HJ, Smith MN, Rapp F (1971) Intracellular branched tubular structures in osteosarcoma. Cancer 27: 1440–1448Google Scholar
  22. 22.
    Kobayasi T, Asboe-Hansen G (1972) Granules of Langerhans cells in Letterer-Siwe's disease. Acta Derm Venereol (Stockh) 52: 257–262Google Scholar
  23. 23.
    Norton WL (1969) Endothelial inclusions in active lesions of systemic lupus erythematosus. J Lab Clin Med 74: 369–379Google Scholar
  24. 24.
    Olmos L, Hunziker N, Laugier P (1979) Microcylinders of endoplasmic reticulum in histiocytes in patients suffering from Degos' syndrome and dermatomyositis. Br J Derm 100: 137–145Google Scholar
  25. 25.
    Pfeifer U, Thomssen R, Legier K, Böttcher U, Gerlich W, Weinmann E, Klinge O (1980) Experimental non-A, non-B hepatitis: four types of cytoplasmic alteration in hepatocytes of infected chimpanzees. Virchows Arch [Cell Pathol] 33: 233–243Google Scholar
  26. 26.
    Pincus T, Blacklow NR, Grimley PM, Bellanti JA (1970) Glomerular microtubules of systemic lupus erythematosus. Lancet II: 1058–1061Google Scholar
  27. 27.
    Popoff NA, Malinin TI (1976) Cytoplasmic tubular arrays in cells of American Burkitt's type lymphoma. Cancer 37: 275–284Google Scholar
  28. 28.
    Pothier L, Uzman BG, Kasac MM, Saito H, Adams RA (1973) Immunoglobulin synthesis and tubular arrays in the endoplasmic reticulum in transplanted human tumors of lymphoid origin. Lab Invest 29: 607–613Google Scholar
  29. 29.
    Prasad U, Gogusev J (1978) Intracisternal tubular inclusions in nasopharyngeal carcinoma. J Laryngol Otol 92: 979–989Google Scholar
  30. 30.
    Reynolds ES, Ree HJ (1971) Liver parenchymal cell injury. VII. Membrane denaturation following carbon tetrachloride. Lab Invest 25: 269–278Google Scholar
  31. 31.
    Schaff Z, Heine U, Dalton AJ (1972) Ultramorphological and ultracytochemical studies on tubuloreticular structures in lymphoid cells. Cancer Res 32: 2696–2706Google Scholar
  32. 32.
    Schaff Z, Barry DW, Grimley PM (1973) Cytochemistry of tubuloreticular structures in lymphocytes from patients with systemic lupus erythematosus and in cultured human lymphoid cells. Comparison to a paramyxovirus. Lab Invest 29: 577–586Google Scholar
  33. 33.
    Schaff Z, Lapis K, Grimley PM (1976) Undulating membraneous structures associated with the endoplasmic reticulum in tumour cells. Int J Cancer 18: 697–702Google Scholar
  34. 34.
    Schenk P (1983) Ultrastrukturelle Alterationen des endoplasmatischen Retikulums in malignen Keratinozyten des Larynxkarzinoms. Laryngol Rhinol Otol (Stuttg) 62: 535–539Google Scholar
  35. 35.
    Shamoto M, Murakami S, Zenke T (1981) Adult T-cell leukemia in Japan: an ultrastructural study. Cancer 47: 1804–1811Google Scholar
  36. 36.
    Smith RD, Deinhardt F (1968) Unique cytoplasmic membranes in Rous sarcoma virus-induced tumors of a subhuman primate. J Cell Biol 37: 819–823Google Scholar
  37. 37.
    Splinter TAW, Helder AW, Lucas CJ, Feltkamp-Vroom TM (1975) Tubuloreticular structures in human lymphoid cell lines. A cell biological study. Br J Exp Pathol 56: 124–132Google Scholar
  38. 38.
    Stingl G (1980) New aspects of Langerhans' cell function. Int J Dermatol 19: 189–213Google Scholar
  39. 39.
    Tandler B, Erlandson RA, Southam CM (1973) Unusual membrane formations in HEp-2 cells infected with Ilheus virus. Lab Invest 28: 217–223Google Scholar
  40. 40.
    Trump BF, Bulger RE (1968) Studies of cellular injury in isolated flounder tubules. IV. Electron microscopic observations of changes during the phase of altered homeostasis in tubules treated with cyanide. Lab Invest 18: 731–739Google Scholar
  41. 41.
    Uzman BG, Saito H, Kasac M (1971) Tubular arrays in the endoplasmic reticulum in human tumor cells. Lab Invest 24: 492–498Google Scholar

Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • P. Schenk
    • 1
  1. 1.Otolaryngology Department IIUniversity of ViennaViennaAustria

Personalised recommendations