Effects of chlorpromazine and diazepam on neuronal activities of the lateral vestibular nucleus in cats
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Summary
The effects of chlorpromazine and diazepam on vestibular neuronal activity were studied in gallamine immobilized cats. Chlorpromazine depressed all the P, N1 and N2-waves of field potentials in the lateral vestibular nucleus evoked by electrical stimulation of the vestibular nerve. Diazepam also reduced the amplitude of postsynaptic components (N1 and N2-waves), while the presynaptic one (P-wave) was slightly increased. Chlorpromazine suppressed the spontaneous as well as the increased vestibular neuronal firing following stimulation of the vestibular nerve. Diazepam enhanced the increased vestibular neuronal firing excited by the nerve stimulation and had no effect on the spontaneous unitary discharges.
Key words
Vestibular Evoked Response Unitary Response Vestibular Nucleus/Physiology Chlorpromazine and Diazepam Animal Experiments CatsPreview
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References
- Adey, W. R., Buchwald, N. A., Lindsley, D. F.: Amygdaloid, pallidal and peripheral influences on mesencephalic unit firing pattern with reference to mechanisms of tremor. Electroenceph. clin. Neurolphysiol. 12, 21 (1960)Google Scholar
- Adey, W. R., Dunlop, C. W.: Amygdaloid and peripheral influences on caudate and pallidal units in the cat and effects of chlorpromazine. Exp. Neurol. 2, 348 (1960)Google Scholar
- Friede, R. L.: Topographic brain chemistry. New York: Academic Press 1966Google Scholar
- Gerbtzoff, M. A.: Cholinesterases. A histochemical contribution to the solution of some functional problems. New York: Pergamon Press 1959Google Scholar
- Jaju, B. P., Kristen, E. B., Wang, S. C.: Effects of belladonna alkaloids on the vestibular nucleus of cat. Amer. J. Physiol. 219, 1248 (1970)Google Scholar
- Jaju, B. P., Wang, S. C.: Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: A search for the locus of their antimotion sickness action. J. Pharmacol. exp. Ther. 176, 718 (1971)Google Scholar
- Matsuoka, I.: Distribution of choline acetylase and cholinesterase and the action of cholinergic drugs on the cat vestibular system. Equilibrium Res. Suppl. 3, 77 (1972)Google Scholar
- Matsuoka, I., Takaori, S., Morimoto, M.: Effects of diphenidol on the central vestibular and visual systems of cats. Jap. J. Pharmacol. 22, 817 (1972)Google Scholar
- Matsuoka, I., Domino, E. F., Morimoto, M.: Adrenergic and cholinergic mechanisms of single vestibular neurons in the cat. Advanc. Oto-Rhino-Laryng. 19, 163 (1973)Google Scholar
- Precht, W., Shimazu, H.: Functional connections of tonic and kinetic vestibular neurons with primary vestibular afferents. J. Neurophysiol. 28, 1014 (1965)Google Scholar
- Shimazu, H., Precht, W.: Tonic and kinetic responses of cat's vestibular neurons to horizontal angular acceleration. J. Neurophysiol. 28, 991 (1965)Google Scholar
- Snider, S. R., Niemer, W. T.: A stereotaxic atlas of the cat brain. Chicago: Univ. of Chicago Press 1961Google Scholar
- Takaori, S., Fukuda, N., Amano, Y.: Mode of action of chlorpromazine on unit discharges from nuclear structures in the brainstem of cats. Jap. J. Pharmacol. 20, 424 (1970)Google Scholar
- Takaori, S., Nakai, Y., Matsuoka, I., Sasa, M., Fukuda, N., Shimamoto, K.: The mechanism of antagonism between apomorphine and metochlopramide on unit discharges from nuclear structures in the brainstem of the cat. Int. J. Neuropharmacol. 7, 115 (1968)Google Scholar
- Zukauskas, E., Machiline, X.: Effects of chlorpromazine on the response patterns of hypothalamic units. Int. J. Neuropharmacol. 3, 341 (1964)Google Scholar