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Archives of oto-rhino-laryngology

, Volume 230, Issue 2, pp 121–132 | Cite as

A contribution to the pathogenesis of cholesteatoma

A histochemical and ultrastructural study
  • W. Mann
  • I. Jonas
  • U. N. Riede
  • Chl. Beck
  • E. Löhle
Article

Summary

In a histochemical and ultrastructural study the pathogenesis of cholesteatoma ostitis is analysed on human tissue. In the subepithelial layer there is evidence of an inflammatory reaction leading to proliferation of granulation tissue with bony invasion. Bony destruction is initiated by osteocytic osteolysis. In the case of cholesteatoma there is a combined action of extraosseous and osseous lysosomal enzymes. The pathological changes of the fibrillar elements suggest that the self-perpetuation of degeneration is maintained by a disturbance of fibrillogenesis. The causal pathogenesis of cholesteatoma formation is discussed as a function of a disturbance between cellular activity, extracellular matrix, and cellular surface.

Key words

Cholesteatoma Histochemistry Ultrastructure Lysosomes Oxytalan fibres 

Ein Beitrag zur Pathogenese des Cholesteatoms

Eine histochemische und ultrastrukturelle Untersuchung

Zusammenfassung

In einer histochemischen und ultrastrukturellen Untersuchung wird die Pathogenese des Cholesteatoms analysiert. Charakteristikum des subepithelialen Gewebes ist die Ausbildung einer entzündlichen Reaktion mit anschließender Formation eines in den Knochen proliferierenden Granulationsgewebes. Der Knochenabbau wird durch osteozytäre Osteolyse eingeleitet. Dadurch kommt es bei der Erkrankung zu einem Zusammenwirken ossär lysosomaler und extraossär lysosomaler Enzyme. Die pathologischen Befunde im Bereich der Faserelemente deuten an, daß der Selbsterhaltungsprozeß der degenerativen Veränderungen durch eine Störung der Fibrillogenese verstärkt wird. Die kausale Genese des Cholesteatoms wird unter Berücksichtigung der gestörten Interaktion zwischen Zellaktivität, Extrazellularmatrix und Zelloberfläche diskutiert.

Schlüsselwörter

Cholesteatom Histochemie Ultrastruktur Lysosomen Oxytalanfaser 

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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • W. Mann
    • 1
  • I. Jonas
    • 2
  • U. N. Riede
    • 3
  • Chl. Beck
    • 1
  • E. Löhle
    • 1
  1. 1.Universitäts-Hals-Nasen-OhrenklinikGermany
  2. 2.Kieferorthopädische Abt. des Zentrums f. Zahn-, Mund- und KieferheilkundeGermany
  3. 3.Zentrum f. Pathologie der UniversitätFreiburg i. Br.Germany

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