, Volume 10, Issue 2, pp 116–125 | Cite as

Central effects of an inhibitor of tyrosine hydroxylation

  • H. Corrodi
  • L. C. F. Hanson
Original Investigations


The selective decrease of noradrenaline and dopamine content in the brain of mice and rats caused by the methylester of Dl-α-methyltyrosine (H 44/68) (an inhibitor of the biosynthesis of these amines) is accompanied by a lowered conditioned avoidance response (CAR) in trained animals.

These two effects have the same time curve and reach a minimum within 8–16 hours. A small dose of d-DOPA refills the dopamine and noradrenaline storage sites in the brain of animals pretreated with H 44/68 and causes an improvement in the conditioned avoidance response.


Dopamine Tyrosine Noradrenaline Central Effect Small Dose 
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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • H. Corrodi
    • 1
  • L. C. F. Hanson
    • 1
  1. 1.Department of PharmacologyUniversity of Göteborg and the Biochemical Laboratory of AB HässleGöteborgSweden

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