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Psychopharmacologia

, Volume 10, Issue 2, pp 116–125 | Cite as

Central effects of an inhibitor of tyrosine hydroxylation

  • H. Corrodi
  • L. C. F. Hanson
Original Investigations

Summary

The selective decrease of noradrenaline and dopamine content in the brain of mice and rats caused by the methylester of Dl-α-methyltyrosine (H 44/68) (an inhibitor of the biosynthesis of these amines) is accompanied by a lowered conditioned avoidance response (CAR) in trained animals.

These two effects have the same time curve and reach a minimum within 8–16 hours. A small dose of d-DOPA refills the dopamine and noradrenaline storage sites in the brain of animals pretreated with H 44/68 and causes an improvement in the conditioned avoidance response.

Keywords

Dopamine Tyrosine Noradrenaline Central Effect Small Dose 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1966

Authors and Affiliations

  • H. Corrodi
    • 1
  • L. C. F. Hanson
    • 1
  1. 1.Department of PharmacologyUniversity of Göteborg and the Biochemical Laboratory of AB HässleGöteborgSweden

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