Archives of Dermatological Research

, Volume 262, Issue 2, pp 153–156 | Cite as

Plasma kinin activation in tranexamic acid treated patients with hereditary angioneurotic edema

  • Grete Lauerberg
Original Papers

Summary

Plasma kinin formation after in vitro activation of factor XII in the coagulation system was examined in 4 patients with hereditary angioneurotic edema. Compared to controls activationcurves showed a steeper increase and higher maximum levels. Administration of tranexamic acid to the patients resulted in partial normalisation of plasma kinin activation.

Key words

Kinin, Factor XII Tranexamic acid Hereditary angioneurotic edema 

Zusammenfassung

Die Plasmakininbildung nach in vitro-Aktivation des Faktors XII im Gerinnungssystem wurde bei 4 Patienten mit hereditärem angioneurotischem Ödem untersucht. Verglichen mit den Kontrollen, zeigten die Aktivkurven einen steileren Anstieg und einen höheren maximalen Spiegel. Die Verabreichung von Tranexansäure, eine der Epsilonaminocapronsäure analoge Verbindung, fürhrte zur teilweisen Normalisation der Plasmakininaktivierung.

Schlüsselwörter

Kinine, Faktor XII Tranexansäure Hereditäres angioneurotisches Ödem 

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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Grete Lauerberg
    • 1
  1. 1.Department of Dermatology, Marselisborg HospitalUniversity of AarhusAarhusDenmark

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