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Diabetologia

, Volume 29, Issue 4, pp 207–210 | Cite as

HLA-DR 3 is associated with a more slowly progressive form of Type 1 (insulin-dependent) diabetes

  • J. Ludvigsson
  • U. Samuelsson
  • C. Beauforts
  • I. Deschamps
  • H. Dorchy
  • A. Drash
  • R. Francois
  • G. Herz
  • M. New
  • E. Schober
Originals

Summary

The presence of HLA-DR 3 was analysed in 745 patients with Type 1 (insulin-dependent) diabetes with age at diagnosis between 1–19 years. HLA-DR 3 and/or 4 was found in 678/745 (91%) of the patients. Presence of DR 2 with neither DR 3 nor 4 was demonstrated in 15 patients. Patients with HLA-DR 3 without DR 4 presented with Type 1 diabetes more evenly over the year; they also presented without incidence peaks at 7 years or 10–11 years, as seen especially in DR 3/4 patients. The DR 3 patients more often had mild disease with less ketonuria at diagnosis, less often ketoacidotic symptoms and more often a subsequent partial remission. The apparently more severe disease among diabetic girls may, at least to some extent, be explained by their higher prevalence of HLA-DR4. The differences found were similar in North America and Europe. The results suggest that Type 1 diabetes is a genetically heterogenous disease and that HLA-typing may be a useful marker of this heterogeneity.

Key words

Type 1 diabetes children HLA-types heterogeneity symptoms at onset partial remission genetic susceptibility 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • J. Ludvigsson
    • 1
  • U. Samuelsson
    • 1
  • C. Beauforts
    • 2
  • I. Deschamps
    • 3
  • H. Dorchy
    • 5
  • A. Drash
    • 8
  • R. Francois
    • 4
  • G. Herz
    • 6
  • M. New
    • 7
  • E. Schober
    • 9
  1. 1.Department of PediatricsUniversity HospitalLinköpingSweden
  2. 2.Sophia Children's HospitalRotterdamThe Netherlands
  3. 3.Department of PediatricsHôpital HéroldParis
  4. 4.Department of PediatricsHôpital HerriotLyonFrance
  5. 5.Department of PediatricsSaint Pierre University HospitalBrusselsBelgium
  6. 6.Department of PediatricsBaselSwitzerland
  7. 7.New York HospitalNew York
  8. 8.Children's HospitalPittsburghUSA
  9. 9.University KinderklinikViennaAustria

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