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Effect of citrate on radial growth and conidiation of the mould Aspergillus nidulans

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A mutation of the ctsA locus of Aspergillus nidulans affects both the radial growth and conidiation of the mould when grown in the presence of citrate. The ctsA locus was allocated to linkage group IV but it recombines freely with inoB2 and pyroA4 (which are also in linkage group IV). It is recessive in heterozygous diploids. A possible role for this gene in maintaining membrane integrity is discussed.

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  1. Arst H.N.Jr., Bailey C.R. & Penfold H.A. 1980 A possible role for acid phosphatase in γ-amino-n-butyrate uptake in Aspergillus nidulans. Archives of Microbiology 125, 153–158.

  2. Arst H.N.Jr. & Cove D.J. 1970 Molybdate metabolism in Aspergillus nidulans. II. Mutations affecting phosphatase activity or galactose utilization. Molecular and General Genetics 108, 146–153.

  3. Azevedo J.L. & Santana E.P. 1975 The use of chloroneb to obtain haploid segregants from heterozygous diploids of Aspergillus nidulans. Aspergillus Newsletter 13, 6.

  4. Bowman B.J. & Bowman E.J. 1986 H+-ATPases from mitochondria, plasma membranes, and vacuoles of fungal cells. Journal of Membrane Biology 94, 83–97.

  5. Caddick M.X. & Arst H.N.Jr. 1986 Structural genes for phosphatases in Aspergillus nidulans. Genetical Research (Cambridge) 47, 83–91.

  6. Caddick M.X., Brownlee A.G. & Arst H.N.Jr. 1986 Regulation of gene expression by pH of the growth medium in Aspergillus nidulans. Molecular and General Genetics 203, 346–353.

  7. Cove D.J. 1966 The induction and repression of nitrate reductase in the fungus Aspergillus nidulans. Biochimica et Biophysica Acta 113, 51–56.

  8. Davis B.D., Chen L. & Tai P.C. 1986 Misread protein creates membrane channels: An essential step in the bactericidal action of aminoglycosides. Proceedings of the National Academy of Sciences USA 83, 6164–6168.

  9. Hang Y.D. 1990 Toxic action of citric acid on Geotrichum candidum. World Journal of Microbiology and Biotechnology 6, 73–75.

  10. MacRae W.D., Buxton F.P., Sibley S., Garven S., Gwynne D.L., Davies R.W. & Arst H.N.Jr. 1988 A phosphate-repressible acid phosphatase gene from Aspergillus niger: its cloning, sequencing and transcriptional analysis. Gene 71, 339–348.

  11. McCully K.S. & Forbes E. 1965 The use of p-fluorophenylalanine with ‘master strains’ of Aspergillus nidulans for assigning to linkage groups. Genetical Research 6, 352–359.

  12. Pontecorvo G., Roper J.A., Hemmons L.M., Macdonald K.D. & Bufton A.W.J. 1953 The genetics of Aspergillus nidulans. Advances in Genetics 5, 141–238.

  13. Roper J.A. 1952 Production of heterozygous diploids in filamentous fungi. Experientia 8, 14–15.

  14. Rossi A. & Arst H.N.Jr. 1990 Mutants of Aspergillus nidulans able to grow at extremely acidic pH acidify the medium less than wild type when grown at more moderate pH. FEMS Microbiology Letters 66, 51–54.

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The authors are with the Departamento de Genética, FMRP-USP, Av. Bandeirantes, 3900, 14049 Ribeirão Preto, SP., Brazil.

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Pombeiro, S.R.C., Martinez-Rossi, N.M. & Rossi, A. Effect of citrate on radial growth and conidiation of the mould Aspergillus nidulans . World J Microbiol Biotechnol 7, 609–612 (1991).

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Key words

  • Aspergillus nidulans
  • citrate toxicity
  • fungi
  • pH regulation