Advertisement

Naturwissenschaften

, Volume 65, Issue 4, pp 174–179 | Cite as

Toward drugs derived from cannabis

  • R. Mechoulam
  • E. A. Carlini
Article

Abstract

Recent work aimed at the introduction of natural and synthetic cannabinoids as drugs is reviewed. Δ1-Tetrahydrocannabinol (Δ1-THC) is mainly investigated as a potential drug against glaucoma and asthma, and as an antiemetic agent in cancer chemotherapy. Cannabidiol is being tried in the clinic against epilepsy and as a hypnotic. Numerous synthetic cannabinoids are currently being investigated as analgetics and as sedative-relaxants.

Keywords

Asthma Recent Work Glaucoma Potential Drug Cancer Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rosenthal, F.: The Herb Hashish versus Mediaval Muslim Society. Leiden: E.J. Brill 1971Google Scholar
  2. 2.
    Julien, S.: Acad. Sci. [D] (Paris) 28, 195 (1849)Google Scholar
  3. 3.
    Walton, R.P.: Marihuana. America's New Drug Problem. Philadelphia: Lippincott 1938Google Scholar
  4. 4.
    Mikuriya, T.H. (ed.): Marijuana. Medical Papers 1839–1972. Oakland, California: Medi-Comp Press 1973Google Scholar
  5. 5.
    O'Shoughnessy, W.B.: Trans. Med. Phys. Soc. Bombay 421 (1842)Google Scholar
  6. 6.
    Reynolds, J.R.: Lancet 1890-I, 637Google Scholar
  7. 7.
    For a review see: Mechoulam, R. (ed.): Marijuana. Chemistry, Pharmacology, Metabolism and Clinical Effects. New-York: Academic Press 1973Google Scholar
  8. 8.
    Gaoni, Y., Mechoulam, R.: J. Am. Chem. Soc. 86, 1646 (1964)Google Scholar
  9. 9.
    Mechoulam, R., Burstein, S., McCallum, N.K.: Chem. Rev. 76, 75 (1976); Braude, M.C., Czara, S. (eds.): Pharmacology of Marihuana. New York: Raven Press 1976; Graham, J.D.P. (ed.): Cannabis and Health. London-New York: Academic Press 1976Google Scholar
  10. 10.
    Benowitz, N.L., Jones, R.T.: Clin. Pharmacol. Ther. 21, 336 (1977)Google Scholar
  11. 11. a)
    Cohen, S., Stillman, R.C. (ed.): The Therapeutic Potential of Marihuana. New York: Plenum Med. Book Co. 1976Google Scholar
  12. 11. b)
    Archer, R.A.: Ann. Rep. Med. Chem. 9, 253 (1974)Google Scholar
  13. 12.
    Hepler, R.S., Frank, I.M.: JAMA 217, 1392 (1971)Google Scholar
  14. 13.
    Hepler, R.S., Petrus, R.J., in: [11a], p. 63Google Scholar
  15. 14.
    Mechoulam, R., et al., in: [11a], p. 35.Google Scholar
  16. 15.
    Green, K., Kim, K.: Proc. Soc. Exp. Biol. Med. 154, 228 (1977)Google Scholar
  17. 16.
    Vachon, L., et al.: N. Engl. J. Med. 288, 985 (1973)Google Scholar
  18. 17.
    Tashkin, D.P., Shapiro, B.J., Frank, I.M.: Am. Rev. Resp. Dis. 109, 420 (1974)Google Scholar
  19. 18.
    Vachon, L., Robins, A., Gaensler, E.A., in: [11a], p. 111Google Scholar
  20. 19.
    Tashkin, D.P., et al.: Am. Rev. Resp. Dis. 115, 57 (1977)Google Scholar
  21. 20.
    Abboud, R.T., Sanders, H.D.: Chest 70, 480 (1976)Google Scholar
  22. 21.
    Salan, S.E., Zinberg, N.B., Frei, E.: N. Engl. J. Med. 293, 795 (1975)Google Scholar
  23. 22.
    Benowitz, N.L., Jones, R.T.: Clin. Pharmacol. Ther. 18, 287 (1975)Google Scholar
  24. 23.
    Sofia, R.D., et al.: J. Pharmacol. Exp. Ther. 186, 646 (1973); Sofia, R.D., et al.: Life Sci. 15, 251 (1974)Google Scholar
  25. 24.
    Kosersky, D.S., Dewey, W.L., Harris, L.S.: Eur. J. Pharmacol. 24, 1 (1973)Google Scholar
  26. 25.
    Gordon, R., Gordon, R.J., Sofia, R.D.: ibid. 35, 309 (1976)Google Scholar
  27. 26.
    Nir, I., et al.: Nature 244, 470 (1973); Ayalon, D., et al.: Neuroendocrinology 23, 31 (1977)Google Scholar
  28. 27.
    Vitez, T.S., et al.: Anaesthesiology 38, 525 (1973)Google Scholar
  29. 28.
    Cousens, K., DiMascio, A.: Psychopharmacologia 33, 355 (1973)Google Scholar
  30. 29.
    Nahas, G.G. (ed.): Marihuana, Chemistry, Biochemistry, and Cellular Effects. Berlin-Heidelberg-New York: Springer 1976Google Scholar
  31. 30.
    Greenberg, J.H., Saunders, M.E., Mellors, A.: Science 197, 475 (1977)Google Scholar
  32. 31.
    Zimmerman, S., et al.: Pharmacology 15, 10 (1977)Google Scholar
  33. 32.
    Petersen, B.H., Graham, J., Lemberger, L.: Life Sci. 19, 395 (1976); Lau, R.J., et al.: Science 192, 805 (1976); White, S.C., Brin, S.C., Janicki, B.W.: ibid. 188, 71 (1975)Google Scholar
  34. 33.
    Carlini, E.A., et al.: J. Pharm. Pharmacol. 25, 664 (1973)Google Scholar
  35. 34.
    Izquierdo, I., Orsinger, O.A., Berardi, A.C.: Psychopharmacologia 28, 95 (1973)Google Scholar
  36. 35.
    Turkanis, S.A., et al.: Res. Commun. Chem. Pathol. Pharmacol. 2, 213 (1974); Consroe, P., Wolkin, A.: J. Pharmacol. Exp. Ther. 201, 26 (1977)Google Scholar
  37. 36.
    Cunha, J.M., et al.: Abstr. Conf. Psychotropic Drug Action with Special Reference to Cannabinoids, Arad, Israel 1977; work still in progressGoogle Scholar
  38. 37.
    Winek, C.L.: Clin. Toxicol. 10, 243 (1977)Google Scholar
  39. 38.
    Bicher, H.I., Mechoulam, R.: Arch. Int. Pharmacodyn. 172, 24 (1968)Google Scholar
  40. 39.
    Wilson, R.S., May, E.L.: J. Med. Chem. 18, 700 (1975)Google Scholar
  41. 40.
    Burstein, S.H., et al.: Nature 225, 87 (1970); Ben-Zvi, Z., Mechoulam, R., Burstein, S.: J. Am. Chem. Soc. 92, 3468 (1970)Google Scholar
  42. 41.
    Hollister, L.E.: Pharmacology 11, 3 (1974)Google Scholar
  43. 42.
    Wilson, R.S., et al.: J. Med. Chem. 19, 1165 (1976)Google Scholar
  44. 43.
    Martin, B.R., et al.: Res. Commun. Chem. Pathol. Pharmacol. 16, 187 (1977)Google Scholar
  45. 44.
    Lemberger, L., Rowe, H.: Clin. Pharmacol. Ther. 18, 720 (1975); [11a], p. 405.Google Scholar
  46. 45.
    Dren, A.T., in: [11a], p.439Google Scholar
  47. 46.
    Pars, H.G., Razdan, R.K., in: [11a], p.419Google Scholar
  48. 47.
    Sidell, F.R., et al.: Proc. Soc. Exp. Biol. Med. 142, 867 (1973)Google Scholar
  49. 48.
    Mechoulam, R., Edery, H., in: [7], p. 101Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • R. Mechoulam
    • 1
  • E. A. Carlini
    • 2
  1. 1.Department of Natural ProductsHebrew University Pharmacy SchoolJerusalemIsrael
  2. 2.Department of PsychobiologyEscola Paulista de MedicinaSao PaoloBrasil

Personalised recommendations