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Serum level monitoring and therapeutic effect of haloperidol in schizophrenic patients


Haloperidol serum concentrations were determined after IM or oral treatment in 15 schizophrenic patients. No correlation was found between drug levels and therapeutic effect. However, a good relationship was found between the half-life calculated after the first IM injection and the BPRS decrease after 3 weeks. Therefore a serum level study on the first day may forecast the therapeutic response.

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Correspondence to M. A. Moulin.

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Moulin, M.A., Davy, J.P., Debruyne, D. et al. Serum level monitoring and therapeutic effect of haloperidol in schizophrenic patients. Psychopharmacology 76, 346–350 (1982).

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Key words

  • Schizophrenia
  • Haloperidol
  • Serum levels