Malignant melanoma of the conjunctiva: occurrence and survival following surgery and radiotherapy in a Danish population

  • Jens Christian Norregaard
  • Neel Gerner
  • Ove A. Jensen
  • Jan Ulrik Prause
Clinical Investigation


• Purpose: To describe patient characteristics, risk of recurrence, and survival in patients with premalignant and malignant melanocytic lesions of the conjunctiva. • Methods: In a retrospective study, 55 cases with a minimum follow-up of 10 years were reviewed. • Results: The actuarial 5-and 10-year survival rates were 86% (95% Cl: 76–96%) and 73% (95% Cl: 60–87%) respectively. The 5-year risk of local recurrence was 35% (95% Cl: 21–49%), and the 10-year risk was 43% (95% Cl: 28–58%). Primary acquired melanosis with atypia was the first manifestation in 13 cases, malignant melanoma in 42 cases. No significant difference in survival and recurrence was found between the two groups or by gender, location of primary lesion, histological characteristics, or extent of surgical procedure. A minimum incidence of 0.052 cases a year per 100000 in Denmark was calculated. • Conclusion: The results are estimated to represent a nationwide sample of patients. No prognostic factors of significance were identified.


Survival Rate Malignant Melanoma Prognostic Factor Retrospective Study Local Recurrence 
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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Jens Christian Norregaard
    • 1
  • Neel Gerner
    • 1
  • Ove A. Jensen
    • 2
  • Jan Ulrik Prause
    • 2
  1. 1.Department of OphthalmologyHvidovre University HospitalHvidovreDenmark
  2. 2.Eye Pathology InstituteUniversity of CopenhagenCopenhagen ØDenmark

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