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European Journal of Nuclear Medicine

, Volume 9, Issue 5, pp 233–236 | Cite as

Lacrimal gland accumulation of 67Ga-citrate in patients with Sjögren's syndrome

  • Masatada Tanabe
  • Eiichi Hasegawa
  • Nobuhiko Matsuo
  • Toyosato Tamai
  • Katashi Satoh
  • Kanji Kojima
  • Chubun Sato
  • Tetuhide H. Murakami
Article
  • 23 Downloads

Abstract

The extent of 67Ga accumulation in the two lacrimal glands in patients with keratoconjunctivitis sicca (KCS) of Sjögren's syndrome was studied. Of the two main groups one consisted of 69 subjects without ophthalmic complaints (control group), the other consisted of 26 patients with KCS of Sjögren's syndrome. Of the 26 patients with KCS, 7 had been diagnosed as probable KCS (probable sub-group) and the other 19 had been diagnosed definite KCS (definite sub-group). About 3 mCi (111 MBq) 67Ga-citrate was injected IV into each subject and this was followed by scintigraphy at 24, 48, and 72 h after the injection of 67Ga. A positive finding in the lacrimal gland was noted in 64 of 69 subjects (92.7%) in the control group and in 7 of 7 patients (92.7%) in the control group and in 7 of 7 patients (100%) with probable KCS. Three of 19 patients with definite KCS (15.7%) showed positive findings under scintigraphy. When the scintigraphic finding in the lacrimal gland is not positive in patients with suspected KCS of Sjögren's syndrome, they can then be diagnosed with little risk as definite KCS cases. Shirmer's test was performed on subjects in the probable and definite groups. There was statistical significance between the positive and equivocal or negative scintigraphic finding and Schirmer's values. These results suggest a correlation between gallium accumulation in the lacrimal gland and the tear production.

Keywords

Public Health Nuclear Medicine Gallium Main Group Positive Finding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • Masatada Tanabe
    • 1
  • Eiichi Hasegawa
    • 2
  • Nobuhiko Matsuo
    • 4
  • Toyosato Tamai
    • 1
  • Katashi Satoh
    • 1
  • Kanji Kojima
    • 1
  • Chubun Sato
    • 3
  • Tetuhide H. Murakami
    • 3
  1. 1.Department of RadiologyKagawa Medical SchoolKagawaJapan
  2. 2.Department of OphthalmologyKagawa Medical SchoolKagawaJapan
  3. 3.Department of BiologyKagawa Medical SchoolKagawaJapan
  4. 4.Department of OphthalmologyOkayama University Medical SchoolOkayamaJapan

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