Biological activities of mycotoxins

Adamson, R. H., P. Correa & D. W. Dalgard. 1973. Brief Communication: Occurrence of a primary liver carcinoma in a Rhesus monkey fed aflatoxin B₁. J. Natl. Cancer Inst. 549–553.Google Scholar

Alpert, M. E., M. S. R. Hutt & C. S. Davidson. 1969. Primary hepatoma in Uganda, a prospective clinical and epidemiologic study in forty-six patients. Am. J. Med. 46: 794–802.Google Scholar

Alpert, M. E., M. S. R. Hutt, G. N. Wogan & Davidson. 1971. Association between aflatoxin content and hepatoma frequency in Uganda. Cancer 28: 253–260.Google Scholar

Ambrose, A. M. & F. DeEds. 1945. Acute and subacute toxicity of pure citrinin. Proc. Soc. Expt. Biol. Med. 59:289–291.Google Scholar

Ames, B. N., W. E. Durston, E. Yamasaki & F. D. Lee. 1973. Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. USA. 70: 2281–2285.Google Scholar

Ames, D. D., R. D. Wyatt, H. C. Marks & K. W. Washburn. 1976. Effect of citrinin, a mycotoxin produced by Penicillium citrinum, on laying hens and young broiler chicks. Poultry Science 55: 1294–1301.Google Scholar

Amla, I., C. S. Kamala, G. S. Gopalakrishna, A. P. Jayaraj, V. Screenivasamurthy & H. A. B. Paria. 1971. Cirrhosis in children from peanutmeal contaminated by aflatoxin. Am. J. Clin. Nutri. 24: 609–614.Google Scholar

Ayres, J. L., D. L. Lee, J. H. Wales & R. O. Sinnhuber. 1971. Aflatoxin structure and hepatocarcinogenicity in rainbow trout (Salmo gairdneri). J. Natl. Cancer Inst. 46: 561–564.Google Scholar

Bababunmi, E. A. & O. Bassir. 1972. Effects of aflatoxin B₁ on the swelling and adenosine triphosphatase activities of mitochondria isolated from different tissues of the rat. FEBS Letters 26: 102–104.Google Scholar

Bamburg, J. R. & F. M. Strong. 1971. 12, 13-epoxytrichothecenes. pp. 207–292. In Microbial Toxins, Vol. 7. S. Kadis, A. Ciegler & S. J. Ajl (eds.). Academic Press, Inc., N. Y.Google Scholar

Barich, L. L., J. Schwartz & D. Barich. 1961. Toxic liver damage in mice after prolonged intake of elevated doses of griseofulvin. Antibiot. Chemother. 11: 566–571.Google Scholar

Barich, L. L., J. Schwartz & D. Barich. 1962. Oral griseofulvin: A co-carcinogenic agent to methylcholantheneinduced cutaneous tumors. Cancer Res. 22: 53–62.Google Scholar

Bagger, G. 1931. Ergot, and Ergotism. Guerney and Jackson, London.Google Scholar

Barnes, J. M. & W. H. Bulter. 1964. Carcinogenic activity of aflatoxin to rats. Nature (London) 202: 1016.Google Scholar

Barnes, J. M., P. K. C. Austwick, R. L. Carter, F. V. Flynn, G. C. Peristianis & W. N. Aldridge. 1977. Balkan (endemic) nephropathy and a toxin producing strain of Penicillium verrucosum var cyclopium: an experimental model in rats. Lancet, March: 671–675.Google Scholar

Berndt, W. O. & A. W. Hayes. 1977. Effects of citrinin on renal tubular transport function in the rat. J. Environ. Path. Toxicol. 1: 93–103.Google Scholar

Blank, F., O. Chin, G. Just, D. R. Merange, M. B. Shimkin & R. Wieder. 1968. Carcinogens from fungi pathogenic for man. Can. Res. 28: 2276–2281.Google Scholar

Bourgeois, C. H., N. Kechama's, D. S. Comer, S. Harikul, H. Evans, C. Olsen, T. Smith & M. R. Beck. 1969. Udoencephalopathy: Fatal cerebral edema and fatty degeneration of the viscera in Thai children. J. Med. Assoc. Thailand. 52: 553–560.Google Scholar

Brown, M. H., G. M. Szczeck & B. P. Purnealis. 1976. Teratogenic and toxic effects of ochratoxin A in rats. Toxicol. Appl. Pharmacol. 37: 331–338.Google Scholar

Butler, W. H. & J. S. Wigglesworth. 1966. The effects of aflatoxin B₁ on the pregnant rat. Br. J. Pathol. 47: 242–247.Google Scholar

Butler, W. H., M. Greenblatt & W. Lijinsky. 1969. Carcinogenesis in rats by aflatoxin B₁, G₁ and B₂. Cancer Res. 29: 2206–2211.Google Scholar

Carlton, W. W., G. Sansing & G. M. Szczech. 1974. Citrinin mycotoxicosis in beagle dogs. Fd. Cosmet. Toxicol. 12: 479–490.Google Scholar

Carnaghan, R. B. A. 1965. Hepatic tumors in ducks fed a low level of a toxic groundnut meal. Nature (London) 208: 308.Google Scholar

Campbell, T. C. & L. Salamat. 1971. Aflatoxin ingestion and excretion by humans, pp. 271–280. In: I. F. H. Purchase (ed.), Mycotoxins in Human Health. MacMillan Press, Ltd., London.Google Scholar

Chaves-Carballo, E., R. D. Ellifson & M. R. Gomez. 1976. An aflatoxin in the liver of a patient with Reye-Johnson syndrome. Mayo Clin. Proc. 51: 48–50.Google Scholar

Chundliffe, E., M. Cannon & J. Davies. 1974. Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. Proc. Natl. Acad. Sci. U.S.A. 71: 30–34.Google Scholar

Chundliffe, E. & J. E. Davies. 1977. Inhibition of initiation, elongation and termination of eukaryotic protein synthesis by trichothecene fungal toxin. Antimicrobial Agt. Chemother. 11: 491–499.Google Scholar

Ciegler, A., R. W. Detroy & E. B. Lillehoj. 1971. Patulin, penicillic acid and other carcinogenic lactones. pp. 4–178, in: Microbial Toxins, Vol. 6, Fungal Toxins. A. Ciegler, S. Kadis & S. J. Ajl (eds.). Academic Press, N. Y.Google Scholar

Ciegler, A., A. C. Beckwith & L. K. Jackson. 1976. Teratogenicity of patulin and patulin adducts formed with cysteine. Appl. Envirn. Microbiol. 31:664–667.Google Scholar

Clifford, J. I., K. R. Ress & M. E. M. Stevens. 1967. The effect of the aflatoxins B₁, G₁ and G₂ on protein and nucleic acid synthesis in rat liver. Biochem. J. 103: 258–261.Google Scholar

Dailey, R. E., E. Brouwer, A. M. Blaschka, E. Reynaldo, S. Green, W. S. Monlux & D. I. Ruggles. 1977. Intermediate-duration toxicity study of patulin in rats. J. Toxicol. Environ. Health 2: 713–725.Google Scholar

Desaiah, D., A. W. Hayes & I. K. Ho. 1977. Effect of rubratoxin B on ATPase activity in mouse tissue. Toxicol. Appl. Pharmacol. 39: 71–79.Google Scholar

Devivo, D. C. & J. P. Keating. 1976. Reye's syndrome, pp. 175–229, in: I. Schulman (ed.). Advances in Pediatrics. Vol. 22. Yearbook Medical Publishers, Chicago, IL.Google Scholar

Dickens, F. & H. E. H. Jones. 1964. The carcinogenic action of aflatoxin after its subcutaneous injection in the rat. Br. J. Cancer 17: 691–698.Google Scholar

Dickens, R. & H. E. H. Jones. 1965. Further studies on the carcinogenic action of certain lactones and related substances in the rat and mouse. Br. J. Cancer 19: 392–403.Google Scholar

Dickens, F. 1967. Mold products including antibiotics as carcinogens. In: Carcinogenesis: A Broad Critique. Williams and Wilkins, Baltimore, MD.Google Scholar

DiPaola, J. A., J. Elis & H. Erwin. 1967. Teratogenic response by hamster, rat and mice to aflatoxin B₁. Nature (London) 215: 638–639.Google Scholar

DiPaolo, J. A., K. Takano & N. C. Popescu. 1972. Quantitation of chemically induced neoplastic transformation of BALB/₃T₃ cloned cell lines. Cancer Res. 32: 2686–2695.Google Scholar

DiPaolo, J. A., R. L. Nelson, P. J. Donovan & C. H. Evans. 1973. Host-mediated in vitro-in vitro assay for chemical carcinogenesis. Arch. Path. 95: 380–385.Google Scholar

Doherty, W. P. & T. C. Campbell. 1973. Aflatoxin inhibition of rat liver mitochondria. Chem-Biol. Interactions 7: 63–77.Google Scholar

Doster, R. C., R. O. Sinnhuber, J. H. Wales & D. J. Lee. 1971. Acute toxicity and carcinogenicity of ochratoxin in rainbow trout (Salmo gairdneri). Fed. Proc. 30: 578.Google Scholar

Elis, J. & J. A. DiPaolo. 1967. Aflatoxin B₁-Induction of malformations. Arch. Pathol. 83: 53–57.Google Scholar

Engel, G. & K. E. Von Milczewski. 1976. Zum Nachweis von Mykotoxinen Nach Activierung mit Rattenleberhomogenaten mittels histidin-mangel mutanten von Salmonella typhimurium. K. milchwert Forsch. 28: 359–366.Google Scholar

Enomoto, M. & I. Ueno. 1974. Penicillium islandicum (toxic yellowed rice) — luteoskyrin — islanditoxin — cyclo-chlorotine. pp. 302–326, in: Mycotoxins. I. F. H. Purchase (ed.). Elsevier. Amsterdam.Google Scholar

Epstein, S. S. & H. Shafner. 1968. Chemical mutagens in the human environment. Nature (London) 219: 385–387.Google Scholar

Evans, M. A. & R. D. Harbison. 1977. Prenatal toxicity of rubratoxin B and its hydrogenated analog. Toxicol. Appl. Pharmacol. 39: 13–22.Google Scholar

Farb, R. M., J. L. Mego & A. W. Hayes. 1976. Effect of mycotoxins on uptake and degradation of ¹²⁵I-albumin in mouse liver and kidney lysosomes. J. Toxicol. Environ. Health 1: 985–990.Google Scholar

Forgacs, J. 1962. Mycotoxicoses-the neglected disease. Foodstuffs 34: 124–134.Google Scholar

Garner, R. C. 1973. Microsome-dependent binding of aflatoxin B₁ to DNA, RNA, polyribonucleotides and protein in vitro. Chem.-Biol. Interact. 6: 125–129.Google Scholar

Gelboin, H. V., J. S. Wortham, R. G. Wilson, M. Friedman & G. N. Wogan. 1966. Rapid and marked inhibition of rat-liver RNA polymerase by aflatoxin B₁. Science 154: 1205–1206.Google Scholar

Hayes, A. W. 1977. Effect of patulin on oxygen consumption of Krebs cycle intermediates. Toxicol. Appl. Pharmacol. 41: 165.Google Scholar

Hayes, A. W., R. E. King, P. D. Unger, T. D. Phillips, J. Hatkin & J. H. Bowen. 1978. Aflatoxicosis in Swine. Am. J. Vet. Med. (in press).Google Scholar

Hayes, A. W., R. D. Phillips & L. C. Wallace. 1977. Effect of penitrem A on mouse liver composition. Toxicon 15: 293–300.Google Scholar

Hayes, A. W., T. D. Phillips & W. L. Williams. 1978. Acute toxicity of patulin. Toxicol Appl. Pharmacol. (in press).Google Scholar

Hayes, A. W. & R. D. Hood. 1978. Effects of prenatal administration of penicillic acid and penitrem A in mice. Toxicon. 16: 92–96.Google Scholar

Hayes, A. W. & W. L. Williams. 1977. Acute toxicity of aflatoxin B₁ and rubratoxin B in dogs. J. Environ. Path. Toxicol. 1: 59–70.Google Scholar

Hayes, A. W. 1976. Action of rubratoxin B on mouse liver mitochondria. Toxicol. 6: 253–261.Google Scholar

Hayes, A. W., D. B. Presley & (J. A. Neville. 1976. Acute toxicity of penitrem A in dogs. Toxicol. Appl. Pharmacol. 35: 311–320.Google Scholar

Hayes, A. W., R. D. Hood & H. L. Lee. 1974. Teratogenic effects of ochratoxin Ain mice. Teratology 9: 93–98.Google Scholar

Hepinstall, R. H. 1974. Pathology of Balkan nephropathy. pp. 28–41, in: Pathology of the kidneys. Academic Press, N. Y.Google Scholar

Hood, R. D., A. W. Hayes & J. G. Scammell. 1976. Effect of citrinin and viriditoxin in prenatal development. Fd. Cosmet. Toxicol. 14: 175–178.Google Scholar

Hood, R. D., M. J. Naughton & A. W. Hayes. 1976. Prenatal effects of ochratoxin A in hamsters. Teratology 13: 11–14.Google Scholar

Hood, R. D., J. E. Innes & A. W. Hayes. 1973. Effects of rubratoxin B on prenatal development in mice. Bull. Environ. Contamin. Toxicol. 10: 200–207.Google Scholar

Hsieh, D. P. H., A. S. Salhab, J. J. Wong & S. L. Yang. 1974. Toxicity of aflatoxin Q₁ as evaluated with the chick enbryo and bacterial auxotrophs. Toxicol. Appl. Pharmacol. 30: 237–242.Google Scholar

Hurst, E. W. & G. E. Paget. 1963. Protoporphyrin, cirrhosis and hepatomas in the livers of mice given griseofulvin. Br. J. Dermatol. 75: 105–109.Google Scholar

LeBreton, E., C. Frayssinet, C. Lafarge & A. M. DeRecondo. 1964. Aflatoxine-mecanisme de l'Action. Fd. Cosmet. Toxicol. 2: 675–676.Google Scholar

Keen, P. & P. Martin. 1971. Is aflatoxin carcinogenic in man? The evidence in Swaziland. Trop. Geogr. Med. 23: 44–53.Google Scholar

Krishnamachari, K. A., V. R. Nagarjan, R. V. Bhat & T. B. G. Telak. 1975. Hepatitis due to aflatoxicosis: an outbreak in Western India. Lancet, May 10: 1061–1063.Google Scholar

Krogh, P. 1976. Mycotoxic nephropathy. Adv. Vet. Sci. Comparative Med. 20: 147–169.Google Scholar

Krogh, P., B. Hald, R. Pestina & S. Ceovic. 1977. Balkan endemic) nephropathy and foodborne ochratoxin A: Preliminary results of a survey of foodstuffs. Acta path. microbiol. Scand. Sect. B, 85: 238–240.Google Scholar

Krogh, P., B. Hald & E. J. Pedersen. 1973. Occurrence of ochratoxin A and citrinin in cereals associated with mycotoxic porcine nephropathy. Acta path. microbiol. Scand. Section B 81: 689–695.Google Scholar

Kuczuk, M. H., P. M. Benson, H. Heath & A. W. Hayes. 1978. Evaluation of the mutagenic potential of mycotoxins using Salmonella typhimurium and Saccharomyces cerevisiae. Mutation Res. 53: 11–20.Google Scholar

Leonard, A., G. DeKnudt & G. Linden. 1975. Mutagenicity tests with aflatoxins in the mouse. Mutation Res. 28: 137–139.Google Scholar

V. W. Legator & M. S. Legator. 1969. Production of petite mutants of Saccharomyces cerevisiae by patulin. Agr. Food Chem. 17: 979–983.Google Scholar

McCann, J., N. E. Spingain, J. Kubori & B. N. Ames. 1975. Detection of carcinogens as mutagens: bacterial tester strains with R. factor plasmids. Proc. Natl. Acad. Sci., U.S.A. 72: 979–983.Google Scholar

Meisner, H. & S. Chan. 1974. Ochratoxin A, an inhibitor of mitochondrial transport systems. Biochem. 13: 2795–2800.Google Scholar

Mego, J. L. & A. W. Hayes. 1973. The effect of fungal toxins on the uptake and degradation of formaldehydetreated ¹²⁵I-albumin in mouse liver phagolysosomes. Biochem. Pharmacol. 22: 3275–3286.Google Scholar

Moore, J. H. & B. Truelove. 1970. Ochratoxin A: inhibitor of mitochondrial respiration. Science 168: 1102–1103.Google Scholar

More, J. & P. Goltier. 1974. Toxicite de l'ochratoxine A. I. effect embroytoxique et teratogene chez le rat. Ann. Rech. Veter. 5: 167–178.Google Scholar

Moroeanu, S. B. 1967. Epidemiological observations on the edemic nephropathy in Rumania, pp. 4–13, in: G.E.W. Wolstenholme & J. Knight (eds.). The Balkan nephropathy. Little, Brown and Co., Boston, MA.Google Scholar

Newberne, P. M. 1974. Mycotoxins: Toxicity, carcinogenicity and the influence of various nutritional conditions. Environ. Health Perspect. 9: 1–32.Google Scholar

Newberne, P. M. 1965. Carcinogenicity of aflatoxin contaminated peanut meal. pp. 187–208, in: G. N. Wogan (ed.) Mycotoxins in Foodstuffs. M.I.T. Press, Cambridge, MA.Google Scholar

Newberne, P. M., R. Russo & G. N. Wogan. 1966. Acute toxicity of aflatoxin B₁ in the dog. Path. Vet. 3: 331–340.Google Scholar

Ong, T. 1970. Mutagenicity of aflatoxins in Neurospora crassa. Mutation Res. 9: 615–618.Google Scholar

Ong, T. 1975. Aflatoxin Mutagenesis. Mutation Res. 32: 35–53.Google Scholar

Patterson, D. S. P., B. J. Shreeve & B. A. Roberts. 1977. (personal communication).Google Scholar

Patterson, D. S. P. 1973. Metabolism as a factor in determining the toxic action of the aflatoxins in different animal species. Fd. Cosmet. Toxicol. 11: 287–294.Google Scholar

Payet, M., J. Cros, C. Quenum, M. Sankale & M. Moulanier. 1966. Deux observations d'enfants ayart consumme de facon prolongee des farines souillees par Aspergillus flavus. La Press Medicale 74: 649–651.Google Scholar

Peers, F. G., C. A. Gilman & C. A. Linsell. 1976. Dietary aflatoxins and human liver cancer. A study in Swaziland. Int. J. Cancer 17: 167–176.Google Scholar

Peers, F. G. & C. A. Linsell. 1973. Dietary aflatoxins and liver cancer a population based study in Kenya. Br. J. Cancer 27: 473–484.Google Scholar

Phillips, T. D. & A. W. Hayes. 1977. Effects of patulin on adenosine triphosphatase in mouse tissues. Toxicol. Appl. Pharmacol. 42: 175–187.Google Scholar

Phillips, T. D. & A. W. Hayes. 1977. Effects of patulin on substrate and cationic ligand activation kinetics of ATPase in mouse brain. J. Pharmacol. Expt. Therap. 205.Google Scholar

Phillips, T. D., D. Desaiah, A. W. Hayes & I. K. Ho. 1978. Unpublished data.Google Scholar

Phillips, R. D. & A. W. Hayes. 1978. Effect of citrinin on composition of mouse liver and kidney. Toxicon 16.Google Scholar

Purchase. I.F.H. & J.J. van der Watt. 1970. Carcinogenicity of sterigmatocystin. Fd. Cosmet. Toxicol. 8: 289–294.Google Scholar

Purchase, I. F. H. & T. Goncalves. 1971. Preliminary results from food analysis in the Inhambane area. pp. 263–269, in: I. F. H. Purchase (ed.). Mycotoxins in human health. MacMillan Press, Ltd., London.Google Scholar

Ramachandra Pai, M. N. Jayanthi Bai & T. A. Venkitasubramanian. 1975. Effect of aflatoxins on ATPase activity of rat liver mitochondria. Bull. Environ. Contamin. Toxicol. 13: 638–640.Google Scholar

Ramadoss, C. S. & E. R. B. Shanmugasundaram. 1973. Effect of citrinin on liver metabolism in rabbits. Indian J. Biochem. Biophys. 10: 296–297.Google Scholar

Reye, R. D., G. Morgan & J. Baral. 1963. Encephalopathy and fatty degeneration of the viscera. A disease entity of childhood. Lancet 2: 749–752.Google Scholar

Robinson, P. 1967. Infantile cirrhosis of the liver in India with special reference to probable aflatoxin etiology). Clin. Ped. 6: 57–62.Google Scholar

Shank, R. C., C. H. Bourgeois, N. Keschamras & P. Chandavimol. 1971. Aflatoxins in autopsy specimens from Thai children with an acute disease of unknown etiology. Fd. Cosmet. Toxicol. 9: 501–506.Google Scholar

Shank, R. C., G. N. Wogan, J. B. Gibson & A. Nondasuta. 1972. Dietary aflatoxins and human liver cancer. II. Aflatoxins in market foods and foodstuffs of Thailand and Hong Kong. Fd. Cosmet. Toxicol. 10: 61–69.Google Scholar

Shank, R. C., G. N. Wogan & J. B. Gibson. 1972. Dietary aflatoxins and human liver cancer. I. Toxigenic molds in food and foodstuffs of tropical southeast Asia. Fd. Cosmet. Toxicol. 10: 51–60.Google Scholar

Shank, R. C., J. E. Gordon, G. N. Wogan, A. Nondasuta & B. Subhamani. 1972. Dietary aflatoxins and human liver cancer. III. Field survey of rural Thai families for ingested aflatoxins. Fd. Cosmet. Toxicol. 10: 71–84.Google Scholar

Shinohara, Y., M. Arai, K. Hirao, S. Sugihara, K. Nakanishi, H. Tsunoda & N. Ito. 1976. Combination effect of citrinin and other chemicals on rat kidney tumorigenesis. Gann 67: 147–155.Google Scholar

Shreeve, B. J., D. S. P. Patterson, G. A. Pepin, B. A. Roberts & A. E. Wrathall. 1977. Effect of feeding ochratoxin to sows during early pregnancy. Br. Vet. J. 133: 412–417.Google Scholar

Sinnhuber, R. O., D. J. Lee, J. H. Wales, M. K. Landers & A. C. Key. 1970. Aflatoxin M₁, a potent liver carcinogen for rainbow trout. Fed. Proc. 29: 568.Google Scholar

Sinnhuber, R. O., D. L. Lee, J. H. Wales & J. L. Ayres. 1968. Dietary factors and hepatoma in rainbow trout (Salmo gairdneri). II. Co-carcinogenesis by cyclopropenoid fatty acids and the effects of gossypol and altered lipids on aflatoxin-induced liver cancer. J. Natl. Cancer Inst. 41: 1293–1299.Google Scholar

Sisk, D. B., W. W. Carlton & T. M. Curtin. 1968. Experimental aflatoxicosis in young swine. Amer. J. Vet. Res. 29: 1591–1602.Google Scholar

Standford, G. K., R. D. Hood & A. W. Hayes. 1976. Effect of prenatal administration of T-2 toxin to mice. Res. Comm. Chem. Pathol. Pharmacol. 10: 743–746.Google Scholar

Stern, P. 1971. Pharmacological analysis of tremor by cyclopium toxin. Jugoslav. physiol. pharmacol. Acta 7: 187–196.Google Scholar

Stern, M., M. J. Pitout & I. F. H. Purchase. 1971. A comparative study on aflatoxin B₁ metabolism in mice and rats. Brit. J. Cancer 25: 291–297.Google Scholar

Steyn, P. S. 1977. Mycotoxins, excluding aflatoxin, zearaleone and the trichothecenes. In: Mycotoxins in human and animal health. J. V. Rodricks, C. W. Hesseltine & M. A. Mehlman (eds.). Pathotox Publishers, Inc., Park Forest South, IL.Google Scholar

Still, P. E., A. W. Macklin, W. E. Ribelin & E. B. Smalley. 1971. Relationship of ochratoxin A to fetal death in laboratory and domestic animals. Nature (London) 234: 563–564.Google Scholar

Suzuki, S., Y. Kozuka, T. Sathoh & M. Yamazaki. 1975. Studies on the nephrotoxicity of ochratoxin A in rats. Toxicol. Appl. Pharmacol. 34: 479–490.Google Scholar

Swenson, D. H., J. A. Miller & E. C. Miller. 1973. 2,3-dihydro-2,3-dehydroxy-aflatoxin B₁: an acid hydrolysis product of an RNA-aflatoxin B₁ adduct formed by hamster and rat liver microsomes in vitro. Biochem. Biophys. Res. Commun. 53: 1260–1267.Google Scholar

Tung, T. C. & K. H. Ling. 1968. Study on aflatoxin of foodstuffs in Taiwan. J. Vitaminology 14: 48–52.Google Scholar

Ueno, Y. & K. Kubota. 1976. DNA-attaching ability of carcinogenic mycotoxins in recombination-deficient mutant cells of Bacillus subtilis. Can. Res. 36: 445–451.Google Scholar

Ueno, Y., I. Ueno, N. Sato, Y. Iitoi, M. Saito, M. Enomoto & H. Tsunoda. 1971. Toxicological approaches to (+) rugulosin, an anthraquinoid mycotoxin of Penicillium regulosum Thom. Japan J. Exptl. Med. 41: 177–188.Google Scholar

Uraguchi, K., M. Saito, Y. Noguchi, K. Takahashi, M. Enomoto & T. Tatsuno. 1972. Chronic toxicity and carcinogenicity in mice of the purified mycotoxins, lukoskyrin and cyclochlorotine. Fd. Cosmet. Toxicol. 10: 193–207.Google Scholar

Van Rensburg, S. J., J. J. Van der Watt, I. F. H. Purchase L. Periera Coutinho & R. Markham. 1974. Primary cancer rate and aflatoxin intake in a high cancer area. S. A. Med. J. 48: 2508a-2508d.Google Scholar

Vesselinvitch, S. D., N. Mihailovich, G. N. Wogan, L. S. Lombard & K. V. N. Rao. 1972. Aflatoxin B₁, a hepatocarcinogen in the infant mouse. Cancer Res. 32: 2289–2291.Google Scholar

Watson, S. A. & A. W. Hayes. 1977. Evaluation of possible sites of action of rubratoxin B induced polyribosomal disaggregation. J. Toxicol. Environ. Health 2: 639–650.Google Scholar

Williams, D. J. & B. R. Rabin. 1969. The effects of aflatoxin B₁ and steroid hormones on polysome binding to microsomal membrane as measured by the activity of an enzyme catalyzing disulphide interchange. FEBS Letters 4: 103–107.Google Scholar

Wilson, B. J., T. Hoekman & W. D. Dettbain. 1972. Effects of a fungus tremorgenic toxin (penitrem A) on transmission in rat phrenic nerve-diaphragm preparations. Brain Res. 40: 540–544.Google Scholar

Wilson, B. J. 1971. Miscellaneous Penicillium toxins, pp. 459–521, in: Microbial Toxins, Vol. 6. Fungal Toxins. A. Ciegler, S. Kadis and S. J. Ajl (eds.). Academic Press, N. Y.Google Scholar

Wilson, B. J., C. H. Wilson & A. W. Hayes. 1968. Tremorgenic toxin from Penicillium cyclopium grown on food materials. Nature (London) 220: 77–78.Google Scholar

Wilson, B. J., P. A. Teer, G. H. Barney & F. R. Blood. 1967. Relationship of aflatoxin to epizootics of toxic hepatitis among animals in southern United States. Amer. J. Vet. Res. 28: 1217–1230.Google Scholar

Wogan, G. N. 1976. Aflatoxins and their relationship to hepatocellular carcinoma, pp. 25–41 in: K. Okieda & R. L. Peters (eds.). Hepatocellular Carcinoma. John Wiley and Sons, N. Y.Google Scholar

Wogan, G. N. 1973. Aflatoxin carcinogenesis. Methods Cancer Res. 7: 309–344.Google Scholar

Wogan, G. N., G. S. Edwards & P. M. Newberne. 1971. Structure-activity relationship in toxicity and carcinogenicity of aflatoxins and analogs. Cancer Res. 31: 1936–1942.Google Scholar

Wogan, G. N. & P. M. Newberne. 1967. Dose-response characteristics of aflatoxin B₁ carcinogenesis in rat. Cancer Res. 27: 2370–2376.Google Scholar

Wong, J. J. & D. P. H. Hsieh. 1976. Mutagenicity of aflatoxins related to their metabolism and carcinogenic potential. Proc. Natl. Acad. Sci., U.S.A. 73: 2241–2244.Google Scholar

Wright, J. & D. C. Morley. 1958. Encephalitis tremens. Lancet 1: 871–873.Google Scholar

Wyatt, R. D., P. B. Hamilton, W. M. Colwell & A. Ciegler. 1972. The effect of tremortin A on chickens. Avian Dis. 16: 461–464.Google Scholar

Yu, F. 1977. Mechanism of aflatoxin B₁ inhibition of rat hepatic nuclear RNA synthesis. J. Biol. Chem. 252: 3245–3251.Google Scholar