Archives of Microbiology

, Volume 142, Issue 2, pp 200–203 | Cite as

Effect of 2-deoxyglucose, α-methylglucoside, and glucosamine on aflatoxin production by Aspergillus parasiticus

  • Robert L. Buchanan
  • Lori A. Ocker
  • Heidi G. Stahl
Short Communications


The effects of 2-deoxyglucose (2-DOG), α-methylglucoside (α-MG), and glucosamine (GA) on aflatoxin production by Aspergillus parasiticus were studied using conidia-initiated and replacement cultures. In conidia-initiated, 2-DOG, α-MG, and GA supported varying amounts of growth when employed as sole carbon sources. In both conidia-initiated and replacement cultures, 2-DOG, but not α-MG nor GA, as sole carbon sources support toxin formation. None of the compounds inhibited aflatoxin production when used in combination with glucose. It appears that neither 2-DOG, α-MG, nor GA can be considered nonmetabolizable analogs of glucose in A. parasiticus.

Key words

Aflatoxins Aspergillus parasiticus Glucose analogs 



yeast extract sucrose


peptone-mineral salts








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  1. Buchanan RL, Ayres JC (1976) Effect of sodium acetate on growth and aflatoxin production by Aspergillus parasiticus NRRL 2999. J Food Sci 41:128–132Google Scholar
  2. Buchanan RL, Houston WM (1982) Production of blue-fluorescent pyrazines by Aspergillus parasiticus. J Food Sci 47:779–782Google Scholar
  3. Buchanan RL, Lewis DF (1984a) Caffeine inhibition of aflatoxin synthesis: Probable site of action. Appl Environ Microbiol 47:1216–1220Google Scholar
  4. Buchanan RL, Lewis DF (1984b) Regulation of aflatoxin biosynthesis: Effect of glucose on the activities of various glycolytic enzymes. Appl Environ Microbiol 48:306–310Google Scholar
  5. Buchanan RL, Stahl HG (1984) Ability of various carbon sources to induce and support aflatoxin synthesis by Aspergillus parasiticus. J Food Safety 6:59–67Google Scholar
  6. Davis ND, Diener UL, Eldridge DW (1966) Production of aflatoxins B1 and G1 by Aspergillus flavus in a semisynthetic medium. Appl Microbiol 14:378–380Google Scholar
  7. Romano AH, Kornberg HL (1969) Regulation of sugar uptake by Aspergillus nidulans. Proc Roy Soc 173:475–490Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Robert L. Buchanan
    • 1
  • Lori A. Ocker
    • 1
  • Heidi G. Stahl
    • 1
  1. 1.Eastern Regional Research Service, Agricultural Research ServiceU.S. Department of AgriculturePhiladelphiaUSA

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