Current Genetics

, Volume 15, Issue 4, pp 239–246

A mitochondrial frameshift suppressor maps in the tRNASer-var1 region of the mitochondrial genome of the yeast S. cerevisiae

  • Brigitte Weiss-Brummer
  • Hajime Sakai
  • Alexander Hüttenhofer
Original articles

Summary

A polypeptide chain-terminating mutation (M5631) previously has been shown to be a +1T insertion in the yeast mitochondrial gene oxi1, coding for subunit II of the cytochrome c oxidase. A spontaneously arisen frameshift suppressor (mfs-1) that is mitochondrially inherited suppresses this mutation to a considerable extent. The suppressor mutation was mapped by genetic and molecular analyses in the mitochondrial tRNASer-var1 region of the mitochondrial genome of the yeast S. cerevisiae. Genetic analyses show that the suppressor mfs-1 does not suppress other known mitochondrial frameshift mutations, or missense and nonsense mutations.

Key words

Yeast Mitochondrial frameshift suppressor 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Brigitte Weiss-Brummer
    • 1
  • Hajime Sakai
    • 1
  • Alexander Hüttenhofer
    • 1
  1. 1.Institut für Genetik und Mikrobiologie, Lehrstuhl für GenetikUniversität MünchenMünchenGermany

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