Mycopathologia

, Volume 91, Issue 3, pp 165–170 | Cite as

Secretory IgA and secretory component in women affected by recidivant vaginal candidiasis

  • Marta D. Romero -Piffiguer
  • Pedro R. Vucovich
  • Clelia M. Riera
Article

Abstract

Local immunity was evaluated in 47 patients affected by recidivant vaginal candidiasis and 33 control women. IgG, IgA, IgM and secretory component (SC) were determined by single radial immunodiffusion in samples of cervicovaginal secretion. IgG in dosable levels was detected in 17/47 samples (36.2%) and IgA in 15/47 patients (31.9%) whereas in the controls, the incidence was 31/33 (93.9%) for IgG and 24/33 (72.7%) for IgA. The difference was significative (P< 0.001) for both immunoglobulins. Significant differences were not obtained for IgM. The SC was detected in 4/47 cervicovaginal secretions of patients affected by candidiasis (8.5%) whereas in the control samples the incidence was 21/33 (63.6%) (P<0.001). In only 2/15 patients with dosable levels of IgA (13%) the secretory nature of this immunoglobulin could be shown by its reaction with anti-SC serum. In the control group, secretory IgA was detected in 19/24 cases (79%) (P< 0.001). Serum immunoglobulins levels were normal. The lack of secretory IgA and SC in the secretion could be related to the adherence capacity of the Candida albicans to epithelial cells.

Keywords

Epithelial Cell Control Sample Candida Dosable Level Candida Albicans 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Dr W. Junk Publishers 1985

Authors and Affiliations

  • Marta D. Romero -Piffiguer
    • 1
  • Pedro R. Vucovich
    • 1
  • Clelia M. Riera
    • 1
  1. 1.Cátedra de Inmunología y Serología, Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCórdobaArgentina

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