Advertisement

European Journal of Pediatrics

, Volume 148, Issue 2, pp 143–145 | Cite as

Serum creatinine and creatinine clearance in healthy neonates and prematures during the first 10 days of life

  • N. Gordjani
  • R. Burghard
  • J. U. Leititis
  • M. Brandis
Neonatology

Abstract

Normal serum creatinine (Scr) and creatinine clearance (Ccr) values during the first 10 days of life were obtained in 63 very premature (28–32 weeks of gestation), premature (33–37 weeks) and term infants (38–42 weeks). Scr fell, and Ccr rose less markedly in the very premature infants. Scr was 80 μmol/l on the 1st day of life both in very premature and premature infants, and 77 μmol/l in full-term neonates. After 10 days, Scr was 73, 53 and 35 μmol/l respectively. There was an exponential correlation between Ccr and gestational age, indicating rapid maturation of glomerular function.

Key words

Serum creatinine Creatinine clearance Normal values Neonates Prematures 

Abbreviations

Scr

serum creatinine

Ccr

creatinine clearance

GA

gestational age

GFR

glomerular filtration rate

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Aperia A, Broberger O, Elinder G, Herin P, Zetterström R (1981) Postnatal development of renal function in preterm and full-term infants. Acta Paediatr Scand 70:183–187Google Scholar
  2. 2.
    Assadi FK, John EG, Fornell L, Rosenthal IM (1985) Falsely elevated serum-creatinine concentration in ketoacidosis. J Pediatr 107:562–566Google Scholar
  3. 3.
    Bartels H, Böhmer M, Heierli C (1972) Serum-Kreatinin-Bestimmung ohne Enteiweißen. Clin Chim Acta 37:193–197Google Scholar
  4. 4.
    Bauer JH, Brocks CS, Burch RN (1982) Clinical appraisal of creatinine-clearance as a measurement of glomerular filtration rate. Am J Kidney Dis 2:337–341Google Scholar
  5. 5.
    Bowers LD (1980) Kinetic serum creatinine assays: the role of various factors in determining specificity. Clin Chem 26:551–554Google Scholar
  6. 6.
    Carrie BJ, Golbetz HV, Michaels AB, Myers BD (1980) Creatinine: an inadequate filtration marker in glomerular disease. Am J Med 69:177–182Google Scholar
  7. 7.
    Dubowitz LMS, Dubowitz V, Goldberg C (1970) Clinical assessment of gestational age in the newborn infant. J Pediatr 77:1–10Google Scholar
  8. 8.
    Fawer CL, Torrado A, Guignard JP (1979) Maturation of renal function in full-term and premature infants. Helv Paediatr Acta 34:11–121Google Scholar
  9. 9.
    Feldman H, Guignard JP (1982) Plasma creatinine in the first month of life. Arch Dis Child 57:123–126Google Scholar
  10. 10.
    Goldmann R, Yadley RA, Nourok DS (1967) Comparison of endogenous and exogenous creatinine-clearance in man. Proc Soc Exp Biol Med 126:1611–1614Google Scholar
  11. 11.
    Guignard JP, Torrado A, Da Cunha A, Gautier E (1975) Glomerular filtration rate in the first three weeks of life. J Pediatr 87:268–272Google Scholar
  12. 12.
    Husdan H, Rapaport A (1968) Estimation of creatinine by the Jaffe reaction: a comparison of three methods. Clin Chem 14:222–238Google Scholar
  13. 13.
    Lebel RR, Gutmann FD, Mazumdan DC, Grzgs U (1984) Creatinine determination in ketosis. N Engl J Med 310:1671Google Scholar
  14. 14.
    Moril, Javoie T (1983) Negative ketone interference with kinetic discrete analyzer KDA. Clin Chem 29:733–734Google Scholar
  15. 15.
    Oh W (1981) Renal function and clinical disorders in the neonate. Clin Perinatol 8:215–223Google Scholar
  16. 16.
    Ross B, Cowett RM, Oh W (1977) Renal function of low birth weight infants during the first two months of life. Pediatr Res 11: 1162–1164Google Scholar
  17. 17.
    Schwartz GJ, Haycock GB (1976) Plasma creatinine and urea concentrations in children. J Pediatr 88:828–830Google Scholar
  18. 18.
    Sertel H, Scopes J (1973) Rates of creatinine clearance in babies less than a week of age. Arch Dis Child 48:717–720Google Scholar
  19. 19.
    Shemesh O, Golbetz H, Kriss JP, Myers BD (1985) Limitations of creatinine as a filtration marker in glomerulopathic patients. Kidney Int 28:830–838Google Scholar
  20. 20.
    Siegel SR, Oh W (1976) Renal function as a marker of human fetal maturation. Acta Paediatr Scand 65:481–485Google Scholar
  21. 21.
    Stonestreet BS, Oh W (1975) Plasma creatinine in low birth weight infants during the first three months of life. Pediatrics 61: 788–789Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • N. Gordjani
    • 1
  • R. Burghard
    • 1
  • J. U. Leititis
    • 1
  • M. Brandis
    • 1
  1. 1.Abteilung für Kinderheilkunde der UniversitätMarburgFederal Republic of Germany

Personalised recommendations