In Saccharomyces cerevisiae, diuron blocks the respiration pathway at the level of the bc1 complex. Nuclear diuron-resistant mutations which confer in vitro resistance to mitochondrial NADH oxidase have been identified. Five mutations were found to be clustered at two distinct nuclear loci, DIU3 and DIU4. The distance between the two loci was estimated to be about 36.7 cM. These loci do not appear to be centromere-linked and did not show a linkage to any of the genes coding for bc1 complex subunits. DIU3 and DIU4 loci might, therefore, code for other components of the respiratory chain.
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Beckmann J, Ljungdahl P, Lopez J, Trumpower B (1987) J Biol Chem 262:8901–8909
Beckmann JD, Ljungdahl PO, Lopez JL, Trumpower BL (1987) J Biol Chem 262:8901–8909
Bradford M (1976) Ann Biochem 72:248–254
Colson A-M, Slonimski P (1979) Mol Gen Genet 167:287–288
Colson A-M, Luu The Van, Convent B, Briquet M, Goffeau A (1977) Eur J Biochem 74:521–526
Convent B, Briquet B (1978) Eur J Biochem 82:473–481
Grivellone M, Wu M, Tzagoloff A (1988) J Biol Chem 263:14323–14333
Howell N, Nalty M (1987) Somatic Cell Mol Genet 13:529–597
Legrain M, De Wilde M, Hilger F (1986) Nucleic Acids Res 14:3059–3073
Ljungdahl P, Pennoyer J, Robertson D, Trumpower B (1987) Biochem Biophys Acta 891:227–241
Lucchini G, Carbona M-L, Cocicci M, Sensi M-L (1973) Mol Gen Genet 177:139–143
Mortimer R, Schild D (1985) Microbiol Rev 49:181–213
Perkins D (1949) Genetics 34:607–626
di Rago J-P, Colson A-M (1988) J Biol Chem 263:12564–12570
di Rago J-P, Perea J, Colson A-M (1986) FEBS Lett 208:208–210
Subik J, Ulaszewski S, Goffeau A (1986) Curr Genet 10:665–670
Thierbach G, Michaelis G (1982) Mol Gen Genet 186:501–506
Tzagoloff A, Akai A, Needleman R (1975) J Biol Chem 250:8228–8235
Tzagoloff A, Akai A, Foury F (1976) FEBS Lett 65:391–395
Tzagoloff A, Wu M, Grivellone M (1986) J Biochem Chem 261:17163–17169
Wolf K, Dujon B, Slonimski P (1973) Mol Gen Genet 125:9–52
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Meunier, B., Colson, A. Two nuclearly inherited loci conferring increased diuron resistance to NADH oxidase in Saccharomyces cerevisiae . Curr Genet 15, 31–38 (1989). https://doi.org/10.1007/BF00445749
- Nuclear genes