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Two nuclearly inherited loci conferring increased diuron resistance to NADH oxidase in Saccharomyces cerevisiae

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In Saccharomyces cerevisiae, diuron blocks the respiration pathway at the level of the bc1 complex. Nuclear diuron-resistant mutations which confer in vitro resistance to mitochondrial NADH oxidase have been identified. Five mutations were found to be clustered at two distinct nuclear loci, DIU3 and DIU4. The distance between the two loci was estimated to be about 36.7 cM. These loci do not appear to be centromere-linked and did not show a linkage to any of the genes coding for bc1 complex subunits. DIU3 and DIU4 loci might, therefore, code for other components of the respiratory chain.

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  1. Beckmann J, Ljungdahl P, Lopez J, Trumpower B (1987) J Biol Chem 262:8901–8909

  2. Beckmann JD, Ljungdahl PO, Lopez JL, Trumpower BL (1987) J Biol Chem 262:8901–8909

  3. Bradford M (1976) Ann Biochem 72:248–254

  4. Colson A-M, Slonimski P (1979) Mol Gen Genet 167:287–288

  5. Colson A-M, Luu The Van, Convent B, Briquet M, Goffeau A (1977) Eur J Biochem 74:521–526

  6. Convent B, Briquet B (1978) Eur J Biochem 82:473–481

  7. Grivellone M, Wu M, Tzagoloff A (1988) J Biol Chem 263:14323–14333

  8. Howell N, Nalty M (1987) Somatic Cell Mol Genet 13:529–597

  9. Legrain M, De Wilde M, Hilger F (1986) Nucleic Acids Res 14:3059–3073

  10. Ljungdahl P, Pennoyer J, Robertson D, Trumpower B (1987) Biochem Biophys Acta 891:227–241

  11. Lucchini G, Carbona M-L, Cocicci M, Sensi M-L (1973) Mol Gen Genet 177:139–143

  12. Mortimer R, Schild D (1985) Microbiol Rev 49:181–213

  13. Perkins D (1949) Genetics 34:607–626

  14. di Rago J-P, Colson A-M (1988) J Biol Chem 263:12564–12570

  15. di Rago J-P, Perea J, Colson A-M (1986) FEBS Lett 208:208–210

  16. Subik J, Ulaszewski S, Goffeau A (1986) Curr Genet 10:665–670

  17. Thierbach G, Michaelis G (1982) Mol Gen Genet 186:501–506

  18. Tzagoloff A, Akai A, Needleman R (1975) J Biol Chem 250:8228–8235

  19. Tzagoloff A, Akai A, Foury F (1976) FEBS Lett 65:391–395

  20. Tzagoloff A, Wu M, Grivellone M (1986) J Biochem Chem 261:17163–17169

  21. Wolf K, Dujon B, Slonimski P (1973) Mol Gen Genet 125:9–52

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Correspondence to Anne-Marie Colson.

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Research associate to the National Fund for Scientific Research, Belgium

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Meunier, B., Colson, A. Two nuclearly inherited loci conferring increased diuron resistance to NADH oxidase in Saccharomyces cerevisiae . Curr Genet 15, 31–38 (1989). https://doi.org/10.1007/BF00445749

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Key words

  • Yeast
  • Diuron
  • Respiration
  • Nuclear genes