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Current Genetics

, Volume 2, Issue 1, pp 61–67 | Cite as

Genetics and biochemistry of resistance to axenomycin in Saccharomyces cerevisiae

  • S. Sora
  • O. Ciferri
  • G. Di Pasquale
  • G. E. Magni
Article

Summary

Axenomycin inhibits protein synthesis in vivo and in vitro in Saccharomyces cerevisiae. The antibiotic acts by binding to ribosomes, most probably to the large ribosomal subunit. Mutant strains resistant to axenomycin appear to contain ribosomes that are not inhibited by the antibiotic. The responsible gene has been mapped on the VII chromosome between the centromere and the leu1 gene.

Key words

Axenomycin Ribosome genetics Yeast Protein synthesis 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • S. Sora
    • 1
  • O. Ciferri
    • 2
  • G. Di Pasquale
    • 2
  • G. E. Magni
    • 1
  1. 1.Institute of GeneticsUniversity of MilanMilanoItaly
  2. 2.Institute of Microbiology and Plant PhysiologyUniversity of PaviaPaviaItaly

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