European Journal of Pediatrics

, Volume 148, Issue 4, pp 374–377 | Cite as

Idiopathic infantile arterial calcification with cardiac, renal and central nervous system involvement

  • M. Van Dyck
  • W. Proesmans
  • E. Van Hollebeke
  • G. Marchal
  • Ph. Moerman


Idiopathic infantile arterial calcification was diagnosed in a 2 week old infant with failure to thrive associated with neurological, renal and cardiac signs. Therapy with diphosphonate resulted in a complete resolution of vascular calcifications. At the age of 2 years the child is doing well but requires medical treatment for arterial hypertension.

Key words

Idiopathic infantile arterial calcification Renal infarction Arterial hypertension Congestive heart failure Diphosphonates 


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  1. 1.
    Bryant JA, White WA (1901) A case of calcification of the arteries and obliterative endarteritis associated with hydronephrosis in a child aged 6 months. Guy's Hosp Rep 55:17–28Google Scholar
  2. 2.
    Ivemark BI, k Lagergron C, Ljungqvist A (1962) Generalized arterial calcification associated with hydramnios in two stillborn infants. Acta Paediatr Scand 135:103–110Google Scholar
  3. 3.
    Lussier-Lazaroff J, Fletcher BD (1973) Idiopathic infantile arterial calcification. Roentgen diagnosis of a rare cause of coronary artery occlusion. Pediatr Radiol 1:224–228Google Scholar
  4. 4.
    Marrott PK, Newcombe KD, Becroft DM, Friedlander DH (1984) Idiopathic infantile calcification with survival into adult life. Pediatr Cardiol 5:119–122Google Scholar
  5. 5.
    Meradji M, Villeneuve VH de, Huber J, Bruijn WC, Pearse RG (1978) Idiopathic infantile arterial calcification in siblings: radiologic diagnosis and successful treatment. J Pediatr 92:401–405Google Scholar
  6. 6.
    Milner LS, Heitner R, Thomson PD, Levin SE, Rothberg AD, Beale P, Ninin DT (1984) Hypertension as the major problem of idiopathic arterial calcification of infancy. J Pediatr 105:934–938Google Scholar
  7. 7.
    Moran JJ, Steiner GL (1962) Idiopathic arterial calcification in a 5-year-old child. Am J Clin Pathol 73:521–526Google Scholar
  8. 8.
    Russell RG, Smith R (1973) Diphosphonates. J Bone Joint Surg (Br) 55:66–86Google Scholar
  9. 9.
    Sholler GF, Yu JS, Bale PM, Hawker RE, Celermajer JM, Kozslowski K (1984) Generalized arterial calcification of infancy: three case reports including spontaneous regression with long-term survival. J Pediatr 105:257–260Google Scholar
  10. 10.
    Wait RB, White G, Davis JH (1983) Beneficial effects of verapamil on postischemic renal failure. Surgery 94:276–282Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • M. Van Dyck
    • 1
  • W. Proesmans
    • 1
  • E. Van Hollebeke
    • 1
  • G. Marchal
    • 2
  • Ph. Moerman
    • 3
  1. 1.Department of Pediatrics Renal UnitUniversity Hospital GasthuisbergLeuvenBelgium
  2. 2.Department of RadiologyUniversity of LeuvenLeuvenBelgium
  3. 3.Department of PathologyUniversity of LeuvenLeuvenBelgium

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