European Journal of Pediatrics

, Volume 148, Issue 4, pp 344–348

Chronic renal failure in methylmalonic acidaemia

  • J. H. Walter
  • A. Michalski
  • W. M. Wilson
  • J. V. Leonard
  • T. M. Barratt
  • M. J. Dillon
Metabolic Diseases


The renal function of 12 patients with non vitamin B12 responsive methylmalonic acidaemia has been investigated. Eight patients had reduced glomerular filtration rates, but the plasma creatinine concentration was only raised in those with values of less than 40ml/min per 1.73m2 surface area. The reduction in glomerular filtration was a function of the age and the severity of the disease. Plasma urate concentrations were increased in four patients but this may be secondary to the renal disease rather than its cause.

Key words

Methylmalonic acidaemia Chronic renal failure Tubulo-interstitial nephritis 


51 Cr-EDTA

51-chromium ethylenediamine tetraacetic acid


glomerular filtration rate


methylmalonic acidaemia


surface area


tubular reabsorption of phosphate


urinary albumin/creatinine concentration ratio


urinary lysozyme/creatinine concentration ratio


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • J. H. Walter
    • 1
  • A. Michalski
    • 1
  • W. M. Wilson
    • 2
  • J. V. Leonard
    • 1
  • T. M. Barratt
    • 2
  • M. J. Dillon
    • 2
  1. 1.Department of Child HealthInstitute of Child HealthLondonUK
  2. 2.Department of Paediatric NephrologyInstitute of Child HealthLondonUK

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