, Volume 92, Issue 2, pp 93–99 | Cite as

Experimental pulmonary candidiasis in modified rabbits

II. Immunohistochemical evidence of participation of immune complexes in the formation of fungal lesions in C. albicans-sensitized hosts
  • Toshitsugu Nakamura


Pulmonary lesions induced by an intratracheal inoculation of Candida albicans into rabbits in untreated control, bovine serum albumin (BSA)-sensitized and C. albicans-sensitized groups were examined immunohistochemically to clarify the localization of IgG, IgM and C3. In the control group no inflammatory cells were immunoreactive for IgG and only a few macrophages for IgM and C3, whereas in the BSA- and C. albicans-sensitized groups there were a small number of IgG-positive polymorphonuclear leukocytes and IgM- and C3-positive macrophages in the lesions, the latter group being more prominent. Furthermore, epithelioid granulomatous lesions at the late stage in the C. albicans-sensitized animals showed scattered epithelioid cells containing IgG as well as abundant IgG- and IgM-positive plasma cells. These immunohistochemical results were considered to support the estimation that immune complexes contributed to the modification of fungal lesions in the C. albicans-sensitized hosts, although non-immunological defense mechanisms seemed to be more important in the elimination of the fungus.


Bovine Serum Albumin Candida Plasma Cell Untreated Control Defense Mechanism 
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Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers 1985

Authors and Affiliations

  • Toshitsugu Nakamura
    • 1
  1. 1.Department of PathologyShinshu University, School of MedicineMatsumotoJapan

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