, Volume 97, Issue 1, pp 89–95

A behavioural profile of fluoxetine-induced anorexia

  • P. G. Clifton
  • A. M. C. Barnfield
  • L. Philcox
Original Investigations


Fluoxetine is a specific and long-lasting inhibitor of serotonin reuptake. In free-feeding rats a dose of 10 mg/kg reduced meal size but had no significant effect on meal frequency. Feeding rate during meals was also reduced. Direct observation of behaviour associated with eating suggested that fluoxetine did not act by enhancing sleep or other behaviour patterns that interfere with eating, although the transition from feeding to sleep occured more rapidly after drug treatment. Enhancement of satiety or interference with the sustaining of meals by fluoxetine would be consistent with these data. Rebound feeding after anorexia was not observed in either the meal pattern study or in a separate experiment using schedule fed animals. There was also no clear development of tolerance to the anorectic effect of fluoxetine, and we discuss possible reasons for an association of these two properties.

Key words

Fluoxetine 5HT reuptake inhibitor Anorectic drug Meal patterns Satiety sequence Tolerance 


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  1. Altmann J (1974) Observational study of behaviour: sampling methods. Behaviour 49:227–267Google Scholar
  2. Antin J, Gibbs J, Holt J, Young, RC, Smith GP (1975) Choleocystokinin elicits the complete behavioural sequence of satiety in rats. J Comp Physiol Psychol 89:784–790Google Scholar
  3. Baker TB, Tiffany ST (1985) Morphine tolerance as habituation. Psychol Rev 92:70–108Google Scholar
  4. Blundell JE (1986) Serotonin manipulations and the structure of feeding behaviour. Appetite 7:39–56Google Scholar
  5. Blundell JE, Latham CJ (1978) Pharmacological manipulation of feeding behaviour: possible influences of serotonin and dopamine on food intake. In: Garattini S, Saminin R (eds) Central mechanisms of anorectic drugs. Raven Press, New York, pp 83–109Google Scholar
  6. Burton MJ, Cooper SJ, Popplewell DA (1981) The effect of fenfluramine on the microstructure of feeding and drinking in the rat. Br J Pharmacol 72:621–633Google Scholar
  7. Clifton PG (1987) Analysis of feeding and drinking patterns. In: Rowland N, Toates F (eds) Methods and techniques to study feeding and drinking behaviour. Elsevier Press, Amsterdam, pp 19–35Google Scholar
  8. Clifton PG, Popplewell DA, Burton MJ (1984) Feeding rate and meal patterns in the laboratory rat. Physiol Behav32:369–374Google Scholar
  9. Davies RF, Rossi J, Panksepp J, Bean NJ, Zolovick AJ (1983) Fenfluramine anorexia: a peripheral locus of action. Physiol Behav 30:723–730Google Scholar
  10. Dumont C, Laurent J, Grandadam A, Boissier JR (1981) Anorectic properties of a new long acting serotonin uptake inhibitor. Life Sci 28:1939–1945Google Scholar
  11. Garattini S, Mennini T, Beuclotti C, Invernizzi R, Samanin R (1986) Neurochemical mechanism of action of drugs which modify feeding via the serotonergic system. Appetite 7:15–38Google Scholar
  12. Grinker JA, Drewnowski A, Enns M, Kissileff H (1980) Effects of d-amphetamine and fenfluramine on feeding problems and activity of obese and lean Zucker rats. Pharmacol Biochem Behav 12:265–275Google Scholar
  13. Kim S-H, Wurtman RJ (1988) Selective effects of CGS 10686B, dl-fenfluramine or fluoxetine on nutrient selection. Physiol Behav 42:319–322Google Scholar
  14. Kirkham TC, Blundell JE (1987) Effects of naloxone and naltrexone on meal patterns of freely-feeding rats. Pharmacol Biochem Behav 26:515–520Google Scholar
  15. Kushner LR, Mook DG (1984) Behavioral correlates of oral and postingestive satiety in the rat. Physiol Behav 33:713–718Google Scholar
  16. Liebowitz SF, Shor-Posner G, Maclow C, Grinker JA (1986) Amphetamine: effects on meal patterns and macronutrient selection. Br Res Bull 17:681–689Google Scholar
  17. Popplewell DA (1981) Microstructural analysis of rat feeding: Applications to neurochemical theories of intake control. D Phil Thesis, University of SussexGoogle Scholar
  18. Rowland NE, Carlton J (1983) Different behavioral mechanisms underlie tolerance to the anorectic effects of fenfluramine and quipazine. Psychopharmacology 81:155–157Google Scholar
  19. Rowland NE, Carlton J (1986) Neurobiology of an anorectic drug: Fenfluramine. Prog Neurobiol 27:13–62Google Scholar
  20. Rowland NE, Bartness T, Carlton J, Antelman S, Kocan D (1981) Tolerance and sensitisation of the effects of various anorectics. In: Hoebel BG, Novin D (eds) The neural basis of feeding and reward. Proceedings of “The neural basis of feeding and reward”, Satellite symposium of Society for Neuroscience Annual Meeting, Los Angeles, CaliforniaGoogle Scholar
  21. Rowland NE, Antelman SM, Kocan D (1982) Differences among “serotonergic” anorectics in a cross-tolerance study: to they all act on serotonin systems? Eur J Pharmacol 81:57–66Google Scholar
  22. Siegel S (1975) Evidence from rats that morphine tolerance is a learned process. J Comp Physiol Psychol 89:498–506Google Scholar
  23. Siegel S (1977) Morphine tolerance acquisition as an associative process. J Exp Psychol: Anim Behav Proc 3:1–13Google Scholar
  24. Solomon RL, Corbit JD (1974) An opponent-process theory of motivation: I Temporal dynamics of affect. Psychol Rev 81:119–145Google Scholar
  25. Wong DT, Bymaster FP, Horng JS, Molloy BB (1975) A new selective inhibitor of uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenyl-propylamine. J Pharmacol Exp Ther 193:804–811Google Scholar

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • P. G. Clifton
    • 1
  • A. M. C. Barnfield
    • 1
  • L. Philcox
    • 1
  1. 1.Laboratory of Experimental PsychologyUniversity of SussexBrightonUK

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