Impaired gastric function in children with cow's milk intolerance
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Eight infants with cow's milk intolerance (CMI) were studied for basal and maximal gastric acid secretion and the fasting serum gastrin level. All these patients had clinical malabsorption. Jejunal biopsies revealed subtotal villous atrophy in six children and slight changes in the remaining two.
The mean maximal acid secretion in the infants with CMI was significantly decreased, being 85±78 μmol/h/kg (mean ± SD), as compared with a control group of the same age with a corresponding value of 233±66 μmol/h/kg. The fasting serum gastrin level was elevated, being 104±116 pmol/l in the study group and 37±10 in the controls.
Three infants with CMI underwent gastric biopsy. Marked changes with epithelial degeneration and prominent cellularity in the lamina propria were seen in two patients. The injury was most severe in the antrum of the stomach.
When these patients with CMI were treated with human or soy milk, the maximal acid secretion returned normal in six months.
Key wordsIntolerance to cow's milk Gastric juice Gastric mucosa Gastrin
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- Caldwell, J. H., Tennenbaum, J. I., Bronstein, H. A.: Serum IgE in eosinophilic gastroenteritis. Response to intestinal challenge in two cases. N. Engl. J. Med. 292, 1388–1390 (1975)Google Scholar
- Ferguson, A.: Models of intestinal hypersensitivity. Clinics in Gastroent. 5, 271–288 (1976)Google Scholar
- Halpin, T. C., Byrne, W. J., Ament, M. E.: Colitis, persistent diarrhea, and soy protein intolerance. J. Pediatr. 91, 404–407 (1977)Google Scholar
- Harrison, M., Kilby, A., Walker-Smith, J. A., France, N. E., Wood, C. B. S.: Cow's milk protein intolerance: a possible association with gastroenteritis, lactose intolerance and IgA deficiency. Br. J. Med. 1, 1501–1504 (1976)Google Scholar
- Katz, A. J., Goldman, H., Grand, R. J.: Gastric mucosal biopsy in eosinophilic (allergic) gastroenteritis. Gastroenterol. 73, 705–709 (1977)Google Scholar
- Kokkonen, J., Similä, S., Herva, R.: Gastrointestinal findings in atopic children. (To be published)Google Scholar
- Kokkonen, J., Similä, S.: Gastric function and absorption of vitamin B 12 in children with celiac disease. Eur. J. Pediatr. 1979 (in press)Google Scholar
- Kuitunen, P., Visakorpi, J. K., Savilahti, E., Pelkonen, P.: Malabsorption syndrome with cow's milk intolerance. Clinical findings and course in 54 cases. Arch. Dis. Childh. 50, 351–356 (1975)Google Scholar
- Matthews, T. S., Soothill, J. F.: Complement activation after milk feeding in children with cow's milk allergy. Lancet 1970 II, 893–895Google Scholar
- O'Donoghue, D. P., Lancaster-Smith, M., Johnson, Q. D., Kumar, P. J.: Gastric lesion in dermatitis herpetiformis. Gut 17, 185–188 (1976)Google Scholar
- Shiner, M., Ballard, J., Smith, M. E.: The small-intestinal mucosa in cow's milk allergy. Lancet 1975 I, 136–140Google Scholar
- Strickland, R. G., Bhathal, P. S., Korman, M. G., et al.: Serum gastrin and the antral mucosa in atrophic gastritis. Br. J. Med. 4, 451–453 (1971)Google Scholar
- Walker, W. A.: Antigen handling by the gut. Arch. Dis. Childh. 53, 527–531 (1978)Google Scholar
- Walker-Smith, J.: Cow's milk protein intolerance. Transient food intolerance of infancy. Arch. Dis. Childh. 50, 347–350 (1975)Google Scholar
- Widerlite, L., Trier, J. S., Blacklow, N. R., et al.: Structure of the gastric nucosa in acute infectious non-bacterial gastroenteritis. Gastroent. 68, 425–430 (1975)Google Scholar