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European Journal of Pediatrics

, Volume 136, Issue 3, pp 285–289 | Cite as

Unusual case of progressive systemic sclerosis with onset in early childhood and following infectious mononucleosis

  • J. Urano
  • H. Kohno
  • T. Watanabe
Original Investigations

Abstract

A rare case of infantile progressive systemic sclerosis is reported. A Japanese girl suffered from infectious mononucleosis at the age of 1 year 3 months, and 5 months later she developed edema and sclerosis of the skin. She has been followed up for 4 years and now has grotesque features, with contractures of hands and feet due to advanced systemic sclerosis. The relationship between infectious mononucleosis and progressive systemic sclerosis is discussed.

Key words

Progressive systemic sclerosis Infectious mononucleosis 

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References

  1. 1.
    Ansell BM, Nasseh GA, Bywaters EGL (1976) Scleroderma in childhood. Ann Rheum Dis 35:189–197Google Scholar
  2. 2.
    Beck JS, Anderson JR, Gray KG, Rowell NR (1963) Antinuclear and precipitation autoantibodies in progressive systemic sclerosis. Lancet II:1188–1190Google Scholar
  3. 3.
    Dabich L, Sullivan DB, Cassidy JT (1974) Scleroderma in the child. J Pediatr 85:770–775Google Scholar
  4. 4.
    Furst DE, Clements PJ, Graze P, Gale R, Roberts N (1979) A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma? Arthritis Rheum 22:904–910Google Scholar
  5. 5.
    Jaffe MO, Winkelmann RK (1961) Generalized scleroderma in children, acrosclerotic type. Arch Dermatol 83:402–413Google Scholar
  6. 6.
    Kass H, Hanson V, Patrick J (1966) Scleroderma in childhood. J Pediatr 68:243–256Google Scholar
  7. 7.
    Medsger TA, Masi AT (1971) Epidemiology of systemic sclerosis (Scleroderma). Ann Intern Med 74:714–721Google Scholar
  8. 8.
    Muller SA, Brunsting LS, Winkelmann RK (1959) Calcinosis cutis: Its relationship to scleroderma. AMA Arch Dermatol 80:15–27Google Scholar
  9. 9.
    Penny R (1977) Scleroderma: Pathogenic factors and current management. Aust N Z J Med 8 [Suppl I]:143–148Google Scholar
  10. 10.
    Rapp CE, Hewetson JF (1978) Infectious mononucleosis and the Epstein-Bar virus. Am J Dis Child 132:78–86Google Scholar
  11. 11.
    Seigneurin JM, Lenoir G (1978) Données récentes sur le rôle pathogène du virus Epstein-Barr. Nouv Presse Méd 7:4003–4004Google Scholar
  12. 12.
    Siegel RC (1977) Scleroderma. Med Clin North Am 6:283–297Google Scholar
  13. 13.
    Stögmann W, Sandhofer M, Fritz J (1977) Immunological studies in childhood scleroderma. Eur J Pediatr 124:223–230Google Scholar
  14. 14.
    Talal N (1977) Immunological and viral factors in autoimmune diseases. Med Clin North Am 61 (2):205–215Google Scholar
  15. 15.
    Tuffanelli DL, Winkelmann RK (1961) Systemic scleroderma: a clinical study of 727 cases. Arch Dermatol 84:359–371Google Scholar
  16. 16.
    Velayos EE, Cohen BS (1972) Progressive systemic sclerosis: diagnosis at the age of 4 years. Am J Dis Child 123:57–60Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. Urano
    • 1
  • H. Kohno
    • 1
  • T. Watanabe
    • 1
  1. 1.Department of PediatricsTokyo Teishin HospitalTokyoJapan

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