Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Social withdrawal following amphetamine administration to marmosets

  • 40 Accesses

  • 15 Citations

Abstract

Approaches and leaves from social encounters by marmosets which had received amphetamine injected either intramuscularly or into the nucleus accumbens or caudate nucleus were recorded and used to determine whether social behaviour was disrupted as a result of behavioural competition or more active social withdrawal. The social isolation observed after the marmosets had received an IM injection of amphetamine (2 mg/kg) was not due to drug-induced increases in alternative behaviours. Drugged animals immediately withdrew from social encounters, interrupting their stereotypies in order to do so, whenever they were approached by an undrugged animal. In contrast, the reduced time spent in social encounters following amphetamine injections into the nucleus accumbens (10, 20 or 40 μg) appeared to be a direct consequence of the concurrent increase in locomotion. Animals continued to initiate social encounters despite being hyperactive. Amphetamine injections into the caudate nucleus were without effect on any of the social or individual behavioural measures.

This is a preview of subscription content, log in to check access.

References

  1. Annett LE, Ridley RM, Gamble SJ, Baker HF (1983) Behavioural effects of intracerebral amphetamine in the marmoset. Psychopharmacology 81:18–21

  2. Beckstead RM (1979) An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal projection (prefrontal) cortex in the rat. J Comp Neurol 184:43–62

  3. Dixon WS, Brown MB (1979) BMDP Biomedical computer programs p-series University of California Press, Los Angeles

  4. Dubach MF, Bowden DM (1983) Response to intracerebral dopamine injection as a model of schizophrenic symptomatology. In: Miczek KA (ed) Ethopharmacology: primate models of neuropsychiatric disorders. Liss, New York, pp 157–184

  5. Garver DL, Schlemmer RF, Maas JW, Davis JM (1975) A schizophreniform behavioural psychosis mediated by dopamine. Am J Psychiatry 132:33–38

  6. Hinde RA (1969) Analysing the roles of partners in a behavioural interaction — mother-infant relations in rhesus macaques. Ann NY Acad Sci 159:651–667

  7. Hinde RA, Atkinson S (1970) Assessing the roles of social partners in maintaining social proximity, as exemplified by mother-infant relations in rhesus monkeys. Anim Behav 18:169–176

  8. Kelley AE, Domesick VB, Nauta WJH (1982) The amygdalostriatal projection in the rat. An anatomical study by anterograde and retrograde tracing methods. Neuroscience 7:615–630

  9. Kjellberg B, Randrup A (1972) Changes in social behaviour in pairs of vervet monkeys (Cercopithecus) produced by single, low doses of amphetamine. Psychopharmacologia 26:117

  10. Kling A, Steklis HD (1976) A neural substrate for affiliative behaviour in non-human primates. Brain Behav Evol 13:216–238

  11. Kling A, Lancaster J, Benitone J (1970) Amygdalectomy in the free-ranging vervet (Cercopithecus aethiops). J Psychiatr Res 7:191–199

  12. Lyon M, Robbins TW (1975) The action of central nervous system stimulant drugs: a general theory concerning amphetamine effects. In: Essman W, Valzelli L (eds) Current developments in psychopharmacology, vol 2. Spectrum, New York, pp 79–163

  13. Mather K (1965) Statistical analysis in biology. University Paperbacks Methuen and Co., London

  14. Maxwell AE (1958) Experimental design in psychology and the medical sciences. Methuen and Co., London

  15. Miczek KA (1983) Ethopharmacology: primate models of neuropsychiatric disorders. Progress in clinical and biological research, vol 131. Liss, New York

  16. Miczek KA, Yoshimura H (1982) Disruption of primate social behaviour by d-amphetamine and cocaine: differential antagonism by antipsychotics. Psychopharmacology 76:163–171

  17. Miczek KA, Woolley J, Schilsserman S, Yoshimura H (1981) Analysis of amphetamine effects on agonistic and affiliative behaviour in squirrel monkeys (Saimiri sciureus). Pharmacol Biochem Behav 14 [Suppl 1]:103–107

  18. Mollenauer S, White M, Plotnick R, Pipkin B (1982) Chronic amphetamine: effects on defensive flight in the rat. Pharmacol Biochem Behav 17:381–384

  19. Randrup A, Munkvad I (1974) Pharmacology and physiology of stereotyped behaviour. J Psychiatr Res 11:1–10

  20. Rosvold HE, Mirsky AF, Pribram KH (1954) Influence of amygdalectomy on social behaviour in monkeys. J Comp Physiol Psychol 47:173–178

  21. Rylander G (1971) Stereotype behaviour in man following amphetamine abuse. In: Baker SB deC (ed) The correlation of adverse effects in man with observations in animals. Excerptia Medica, Int Cong Ser 200, Amsterdam, pp 28–31

  22. Schiørring E (1972) Social isolation and other behavioural changes in a group of three vervet monkeys (Cercopithecus) produced by a single, low dose of amphetamine. Psychopharmacologia 26:117

  23. Schiørring E (1977) Changes in individual and social behaviour induced by amphetamine and related compounds in monkeys and man. In: Ellinwood EH, Kilbey M (eds) Cocaine and other stimulants. Plenum Press, New York, pp 481–522

  24. Schiørring E (1979) Social isolation and other behavioural chages in groups of adult vervet monkeys (Cercopithecus aethiops) produced by low, nonchronic doses of d-amphetamine. Psychopharmacology 64:297–302

  25. Schiørring E, Hecht A (1979) Behavioural effects of low, acute doses of d-amphetamine on the dyadic interaction between mother and infant vervet monkeys (Cercopithecus aethiops) during the first six postnatal months. Psychopharmacology 64:219–224

  26. Scraggs PR, Ridley RM (1978) Behavioural effects of amphetamine in a small primate: relative potencies of the d- and l-isomers. Psychopharmacology 59:243–245

  27. Scraggs PR, Ridley RM (1979) Effect of dopamine and noradrenaline blockade on amphetamine-induced behaviour in the marmoset. Psychopharmacology 62:41–45

  28. Scraggs PR, Baker HF, Ridley RM (1979) Interaction of apomorphine and haloperidol: effects on locomotion and other behaviour in the marmoset. Psychopharmacology 66:41–43

  29. Siegel S (1956) Non-parametric statistics for the behavioural sciences. McGraw-Hill, Kogakusha

  30. Stephan H, Baron G, Schwerdtfeger WK (1980) The brain of the common marmoset: a sterotaxic atlas. Springer, Berlin Heidelberg New York

  31. Stevenson MF, Poole TB (1976) An ethogram of the common marmoset (Callithrix jacchus): general behavioural repertoire. Anim Behav 24:428–451

  32. Vogt JL (1978) The social behaviour of a marmoset (Saguinus fuscicollis) group, II: behaviour patterns and social interaction. Primates 19:287–300

  33. Winer BJ (1971) Statistical principles in experimental design. McGraw-Hill, New York

Download references

Author information

Correspondence to L. E. Annett.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Annett, L.E., Ridley, R.M., Gamble, S.J. et al. Social withdrawal following amphetamine administration to marmosets. Psychopharmacology 99, 222–229 (1989). https://doi.org/10.1007/BF00442812

Download citation

Key words

  • Amphetamine
  • Social behaviour
  • Nucleus accumbens
  • Caudate nucleus
  • Marmoset