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Thrombocytopenia: a complication of Kawasaki disease

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Abstract

Thrombocytopenia was observed in 10 (2.0%) of 486 children with Kawasaki disease. In nine of the ten, the minimal paltelet count of 94000±38000 (SD)/mm3 was seen on day 6.8±2.2 (SD) of illness and the platelet counts were elevated to the normal level in 1–2 weeks. Thrombocytopenia in the nine appeared to be caused via coagulation-mediated platelet consumption, while the remaining child was diagnosed as having idiopathic thrombocytopenic purpura. One of the two who had severe coagulation-mediated thrombocytopenia of less than 50000/mm3 developed coronary aneurysms persisting over 1 year.

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Abbreviations

APTT:

Activated partial thromboplastin time

ESR:

Erythrocyte sedimentation rate

FDP:

Fibrinogen/fibrin degradation products

ITP:

Idiopathic thrombocytopenic purpura

PT:

Prothrombin time

SD:

Standard deviation

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Correspondence to T. Hara.

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Hara, T., Mizuno, Y., Akeda, H. et al. Thrombocytopenia: a complication of Kawasaki disease. Eur J Pediatr 147, 51–53 (1988). https://doi.org/10.1007/BF00442611

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Key words

  • Kawasaki disease
  • Thrombocytopenia
  • Aneurysm