Relation between the degree of initial metabolic decompensation and the duration of the remission phase in type I diabetes mellitus
Abstract
In 21 newly diagnosed children with type I diabetes mellitus initial hemoglobin A1c-concentrations, mean insulin requirements during the first 10 days of treatment to recompensate carbohydrate metabolism, duration of glucosuria after diagnosis and duration of remission were determined. Initial hemoglobin A1c-concentration and both mean insulin requirement during the first 10 days of treatment and duration of initial glucosuria showed a highly significant positive correlation. A highly significant, negative correlation was found between the duration of remission and both the mean insulin requirement during the first 10 days of treatment and the duration of initial glucosuria. Thus the present results together with previous findings suggest that the severity of initial metabolic decompensation in diabetes mellitus type I seems to determine at least in part the duration of remission.
Key words
Diabetes mellitus type I Initial metabolic decompensation Duration of remission HbA1cPreview
Unable to display preview. Download preview PDF.
References
- 1.Joslin EP (1959) Treatment of diabetes mellitus, 10th edn. Len and Febiger, PhiladelphiaGoogle Scholar
- 2.National Diabetes Data Group (1979) Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039–1057Google Scholar
- 3.Ludvigson J, Heding LG (1977) C-peptide and juvenile diabetes. Acta Paed Scand Suppl 270:53–60Google Scholar
- 4.Akerblom HK (1980) Definition of a partial remission in insulin dependent, juvenile-onset diabetes mellitus. Acta Paediatr Belg 33:66Google Scholar
- 5.Vetter U, Heinze E, Beischer W, Kohne E, Kleihauer E, Teller WM (1980) Hemoglobin A1c: A predictor for the duration of the remission phase in juvenile insulin dependent diabetic patients. Acta Paediatr Scand 69:481–483Google Scholar
- 6.Pirart J, Lavaux JP (1971) Remission in diabetes. In: Pfeiffer EF (ed) Handbook of diabetes mellitus, vol II. J Lehmann, Munich, pp 443–502Google Scholar
- 7.Mironze J, Selam JL, Pham TC, Mendoza E, Orsetti A (1978) Sustained insulin-induced remission of juvenile diabetes by means of an external artificial pancreas. Diabetologiga 14:223–227Google Scholar
- 8.Ludvigson J (1980) Factors influencing the occurrence and duration of partial remission in childhood diabetes. Acta Paediatr Belg 33:67Google Scholar
- 9.Vetter U, Heinze E, Beischer W, Teller W (1980) Studies on C-peptide secretion during the remission in diabetic children. Acta Paediatr Belg 33:67Google Scholar
- 10.Knip M, Puukka R, Kaar M, Akerblom H (1980) Residual beta-all function, partial remission and metabolic control in diabetic children. Acta Paediatr Belg 33:68–69Google Scholar
- 11.Jackson RL, Onofrio J, Waiches H, Guthrie RA (1973) “The honey moon period”. Partial remission of juvenile diabetes mellitus. Diabetes 22 (Suppl 1):361Google Scholar
- 12.Park BN, Soelchner JS, Gleason RE (1974) Diabetes in remission. Insulin secretory dynamics. Diabetes 23:616Google Scholar
- 13.Schmidt FH (1963) Enzymatische Methode zur Bestimmung von Blut- und Harnzucker unter Berücksichtigung von Vergleichsuntersuchungen mit klassischen Methoden. Internist 4:554Google Scholar
- 14.Beischer W, Keller L, Maas M, Schiefer E, Pfeiffer EF (1976) Human C-peptide, part I: Radioimmunoassay. Klin Wochenschr 54:709Google Scholar
- 15.Huisman TH (1977) The hemoglobinopathies. Techniques of identification. In: Clinical and biochemical analysis, vol 6. Mareel Dekker, New York Basel, pp 126–131Google Scholar