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Distinction between fibrinogen and fibrin degradation products produced during disseminated intravascular coagulation in childhood

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Abstract

Fibrin-fibrinogen degradation products in serum from five children with disseminated intravascular coagulation (DIC) were characterized using a method of immunoabsorption followed by SDS-polyacrylamide gel electrophoresis. All of the samples contained not only fragment D-dimer which was produced on plasmin lysis of cross-linked fibrin, but also fibrinogen degradation products (fragments X, Y and D). These results suggest that both fibrinogenolysis and fibrinolysis take place simultaneously in DIC.

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References

  1. 1.

    Alkjaersig NK, Fletcher AP, Lewis ML, Cole BR, Ingelfinger JR, Robson AM (1976) Pathophysiological response of the blood coagulation system in acute glomerulonephritis. Kindey Int 10:319–328

  2. 2.

    Ellis BC, Stransky A (1961) A quick and accurate method for the determination of fibrinogen in plasma. J Lab Clin Med 58:477–488

  3. 3.

    Gaffney PJ (1975) Distinction between fibrinogen and fibrin degradation products in plasma. Clin Chim Acta 65:109–115

  4. 4.

    Lane DA, Scully MF, Kakkar VV (1976) A method for characterising serum fibrinogen and fibrin degradation products. Thromb Res 9:191–200

  5. 5.

    Lane DA, Preston FE, Van Ross ME, Kakkar VV (1978) Characterization of serum fibrinogen and fibrin fragments produced during disseminated intravascular coagulation. Br J Haematol 40:609–615

  6. 6.

    McKay DG, Muller-Berghaus (1967) Therapeutic implications of disseminated intravascular coagulation. Am J Cardiol 20: 392–410

  7. 7.

    Merskey C, Kleiner GJ, Johnson AJ (1966) Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood 28:1–18

  8. 8.

    Merskey C, Johnson AJ, Harris JU, Wang MT, Swain S (1980) Isolation of fibrinogen-fibrin related antigen from human plasma by immuno-affinity chromatography: its characterization in normal subjects and in defibrinating patients with abruptio placentae and disseminated cancer. Br J Haematol 44: 655–670

  9. 9.

    Pizzo SV, Schwartz ML, Hill RL, McKee PA (1972) The effect of plasmin on the subunit structure of human fibrinogen. J Biol Chem 247:636–645

  10. 10.

    Pizzo SV, Schwartz ML, Hill RL, McKee PA (1973) The effect of plasmin on the subunit structure of human fibrin. J Biol Chem 248:4574–4583

  11. 11.

    Pizzo SV, Taylor LM Jr, Schwartz ML, Hill RC, McKee PA (1973) Subunit structure of fragment D from fibrinogen and cross-linked fibrin. J Biol Chem 248:4584–4590

  12. 12.

    Platt WR (1979) Laboratory diagnosis of coagulation defects. In: Color atlas and textbook of hematology. Lippincott Co, Philadelphia, pp 305–374

  13. 13.

    Yoshioka K, Miyata H, Maki S (1981) Fibrinogen and fibrin derivatives in serum from normal and sick children. Thromb Res 22:25–32

  14. 14.

    Whaun JM, Oski FA (1972) Experience with disseminated intravascular coagulation in a children's hospital. CMA Journal 107:963–967

  15. 15.

    Wolf PL (1973) Disseminated intravascular coagulation: principles of diasgnosis and management. In: Schmer G, Strandjord PE (eds) Coagulation, current research and clinical applications. Academic Press, New York, pp 17–44

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Correspondence to K. Yoshioka.

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Yoshioka, K., Mizuno, S., Miyata, H. et al. Distinction between fibrinogen and fibrin degradation products produced during disseminated intravascular coagulation in childhood. Eur J Pediatr 138, 46–48 (1982). https://doi.org/10.1007/BF00442327

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Key words

  • Disseminated intravascular coagulation
  • Fibrin-fibrinogen degradation products
  • Fibrinogenolysis
  • Fibrinolysis