Fibrin-fibrinogen degradation products in serum from five children with disseminated intravascular coagulation (DIC) were characterized using a method of immunoabsorption followed by SDS-polyacrylamide gel electrophoresis. All of the samples contained not only fragment D-dimer which was produced on plasmin lysis of cross-linked fibrin, but also fibrinogen degradation products (fragments X, Y and D). These results suggest that both fibrinogenolysis and fibrinolysis take place simultaneously in DIC.
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Yoshioka, K., Mizuno, S., Miyata, H. et al. Distinction between fibrinogen and fibrin degradation products produced during disseminated intravascular coagulation in childhood. Eur J Pediatr 138, 46–48 (1982). https://doi.org/10.1007/BF00442327
- Disseminated intravascular coagulation
- Fibrin-fibrinogen degradation products