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Psychopharmacology

, Volume 97, Issue 2, pp 175–178 | Cite as

5HT3 receptor antagonists block morphine- and nicotine-but not amphetamine-induced reward

  • E. Carboni
  • E. Acquas
  • P. Leone
  • G. Di Chiara
Original Investigations

Abstract

The effect of two potent and specific antagonists of 5HT3 receptors, ICS 205-930 and MDL 72222, on the reinforcing properties of amphetamine, morphine and nicotine was studied in rats. Durg-induced reinforcement was assessed by measuring drug-conditioned place preference. ICS 205-930 and MDL 72222 dose-dependently reduced the place preference induced by morphine (1.0 mg/kg SC). At doses of 0.030 mg/kg SC the two antagonists completely blocked morphine-induced place preference while doses of 0.015 mg/kg SC significantly reduced it. ICS 205-930 and MDL 72222 at doses of 0.030 mg/kg SC also prevented the place preference induced by nicotine (0.6 mg/kg SC). In contrast, ICS 205-930 and MDL 72222 up to doses of 0.030 mg/kg SC failed to modify the place preference elicited by amphetamine (1.0 mg/kg SC). The results indicate that 5HT3 receptors are specifically involved in the reinforcing properties of morphine and nicotine.

Key words

Serotonin Morphine Nicotine Amphetamine Reward Rat 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • E. Carboni
    • 1
  • E. Acquas
    • 1
  • P. Leone
    • 1
  • G. Di Chiara
    • 1
  1. 1.Institute of Experimental Pharmacology and ToxicologyUniverstiy of CagliariCagliariItaly

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