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Quantitative and comparative analyses of pro-aggressive actions of benzodiazepines in maternal aggression of rats

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Abstract

The pro-aggressive effects of low doses of benzodiazepines on maternal aggression in rats were studied. Chlordiazepoxide, diazepam, oxazepam and alprazolam produced bell-shaped dose-response curves, with increased aggression at low doses. Only alprazolam significantly reduced aggression at higher doses. A comparison of the drug effects on different aggressive elements revealed that chlordiazepoxide and oxazepam increased the frequency of more elements of the aggressive repertoire than diazepam or alprazolam. Thus, although all benzodiazepine receptor agonists increased aggression, there were significant quantitative differences in their effects.

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References

  1. Fox KA, Guerriero FJ, Zanghi DC (1974) Oxazepam, prazepam and aggression in mice. Pharmacol Res Commun 6:301–306

  2. Leaf RC, Wnek DJ, Gay PE, Corcia RM, Lamon S (1975) Chlordiazepoxide and diazepam induced mouse killing by rats. Psychopharmacologia 44:23–28

  3. Milkowski W, Liepmann H, Zeugner H, Ruhland M, Tulp M (1985) 1,4-Benzodiazepines and 1,5-benzodiazepines. VII. Synthesis and biological activity. Eur J Med Chem 20:345–358

  4. Mos J, Olivier B (1987) Pro-aggressive actions of benzodiazepines. In: Olivier B, Mos J, Brain PF (eds) Ethopharmacology of agonistic behavior in animals and humans. Martinus Nijhoff, Dordrecht, pp 187–206

  5. Mos J, Olivier B, Van der Poel AM (1987) Modulatory actions of benzodiazepine receptor ligands on agonistic behaviour. Physiol Behav 41:265–278

  6. Olivier B (1981) Selective anti-aggressive properties of DU 27725: ethological analysis of intermale and territorial aggression in the male rat. Pharmacol Biochem Behav 14 (S1):61–77

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Correspondence to Jan Mos.

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Mos, J., Olivier, B. Quantitative and comparative analyses of pro-aggressive actions of benzodiazepines in maternal aggression of rats. Psychopharmacology 97, 152–153 (1989). https://doi.org/10.1007/BF00442238

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Key words

  • Maternal aggression
  • Rats
  • Pro-aggressive activity
  • Benzodiazepines