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European Journal of Pediatrics

, Volume 143, Issue 3, pp 191–193 | Cite as

The effect of dopamine administration on the activity of the renin-angiotensin-aldosterone system in sick preterm infants

  • E. Sulyok
  • I. Seri
  • T. Tulassay
  • J. Kiszel
  • T. Ertl
Original Investigations

Abstract

Nine premature infants with birth weight of 1150 to 2500 g and gestational age of 28 to 35 weeks were given dopamine in a dose of 2–4 μg/kg/min to treat cardiopulmonary distress.

In addition to monitoring of blood gases, blood pressure, acid-base balance, urine flow and urinary sodium excretion, plasma renin activity (PRA) and plasma aldosterone concentration (PA) was also determined prior to and during dopamine therapy.

The dopamine-induced increase in urine flow and urinary sodium excretion was associated with a significant increase of PRA from 18.2±5.1 ng/ml/h to 33.0±5.6 ng/ml/h (P<0.025), while PA and blood pressure remained unaltered by dopamine administration.

It is suggested that the angiotensin II-stimulated aldosterone production is overridden by the inhibitory effect of dopamine.

Key words

Premature infants Dopamine Plasma renin activity Plasma aldosterone concentration 

Abbreviations

RAAS

renin-angiotensin-aldosterone system

PRA

plasma renin activity

PA

plasma aldosterone

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • E. Sulyok
    • 1
    • 2
  • I. Seri
    • 1
    • 2
  • T. Tulassay
    • 1
    • 2
  • J. Kiszel
    • 1
    • 2
  • T. Ertl
    • 1
    • 2
  1. 1.Department of Obstetrics and GynecologyUniversity Medical School of PécsPécsHungary
  2. 2.Semmelweis University of BudapestHungary

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