European Journal of Pediatrics

, Volume 135, Issue 3, pp 291–292

Familial occurrence of meconium ileus

  • Jean L. Allan
  • Melissa Robbie
  • P. D. Phelan
  • D. M. Danks
Original Investigations
  • 22 Downloads

Abstract

A recurrence rate for meconium ileus of 39% was found among C.F. affected siblings in a study of 488 families with at least one C.F. child born over a 24 year period. The recurrence rate was highly significant and indicated a familial trend for the occurrence of meconium ileus. The findings of the study support the existence of genetic heterogeneity in cystic fibrosis.

Key words

Meconium ileus Cystic fibrosis Genetic heterogeneity 

References

  1. Allan JL, Robbie M, Phelan PD, Danks DM (1980). The incidence and presentation of cystic fibrosis in Victoria 1955–1978. Aust Paediat J. (in press)Google Scholar
  2. Danks DM, Allan JL, Anderson CM (1965) A genetic study of fibrocystic disease of the pancreas. Ann Hum Genet Lond 28:323–356Google Scholar
  3. Donnison AB, Shwachman H, Gross P (1966) A review of 164 children with meconium ileus seen at the Children's Hospital Medical Centre, Boston. Pediat 37:833–850Google Scholar
  4. Holsclaw DS, Eckstein HB, Nixon HH (1965) Meconium ileus. A 20 year review of 109 cases. Amer J Dis Child 109:101–113Google Scholar
  5. McDonald JA, Trusler GA (1960). Meconium ileus. Eleven year review at the Hospital for Sick Children, Toronto. Canad Med Assn J 83:881–885Google Scholar
  6. Oppenheimer EH, Esterly JR (1962) Observations in cystic fibrosis of the pancreas. II. Neonatal intestinal obstruction. Bull Johns Hopkins Hosp 111:1–13Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • Jean L. Allan
    • 1
    • 2
  • Melissa Robbie
    • 1
    • 2
  • P. D. Phelan
    • 1
    • 2
  • D. M. Danks
    • 1
    • 2
  1. 1.Department of Thoracic MedicineRoyal Children's HospitalMelbourneAustralia
  2. 2.Department of PaediatricsUniversity of MelbourneAustralia

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