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C-reactive protein as an indicator of infection in the immunosuppressed child

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Abstract

C-reactive protein (CRP) concentrations were determined in a prospective fashion in 50 children with malignant disease. In 35 children with active and aggressive disease, but without signs of infection, no significant increase in CRP was detected. Neither did aggressive cytostatic therapy (70 courses) in non-infected children result in an increase.

In bacteriologically proven, and in clinical sepsis-suspected cases, CRP values increased in all cases to levels above 100 mg/l (normal values less than 5 mg/l). Effective antibiotic therapy resulted in a prompt decline in CRP. Viral infections resulted in a much smaller increase.

We conclude that serial measurements of CRP in these immunosuppressed children are of great help in monitoring infections and defining the group that needs antibiotic therapy. The measurement is also a good indicator of the effectiveness of the antibiotic therapy chosen.

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Abbreviations

CRP:

C-reactive protein

WBC:

white blood cell

EMIT:

enzyme immunoassay

References

  1. 1.

    Dinarello CA (1984) Interleukin-1 and the pathogenesis of the acute-phase response. N Engl J Med 311: 1413–1418

  2. 2.

    Gibbons I, Skold C, Rowley GL, Ullman EF (1980) Homogeneous enzyme immunoassay for proteins employing β-galactosidase. Anal Biochem 102: 167–170

  3. 3.

    Harris RI, Stone PCW, Hudson AG, Stuart J (1984) C-reactive protein rapid assay techniques for monitoring resolution of infection in immunosuppressed patients. J Clin Pathol 37: 821–825

  4. 4.

    Nudelman R, Kagan B (1984) C-reactive protein in pediatrics. Adv Pediatr 31: 517–547

  5. 5.

    Peltola H (1983) C-reactive protein in rapid differentiation of acute epiglottitis from spasmodic croup and acute laryngotracheitis. J Pediatr 102: 713–715

  6. 6.

    Peltola H, Saarinen U, Siimes M (1983) C-reactive protein in rapid diagnosis and follow-up of bacterial septicemia in children with leukemia. Pediatr Infect Dis 2: 370–373

  7. 7.

    Peltola H, Laipio M, Siimes M (1984) Quantitative C-reactive protein (CRP) determined by an immunoturbidimetric method in rapid differential diagnosis of acute bacterial and viral diseases of children. Acta Paediatr Scand 73: 273–274

  8. 8.

    Rose PE, Johanson SA, Meakin M, Mackie PH, Stuart J (1981) Serial study C-reactive protein during infection in leukaemia. J Clin Pathol 34: 263–266

  9. 9.

    Schofield KP, Voulgari F, Gozzard DI, Leyland MJ, Beeching NJ, Stuart J (1982) C-reactive protein concentration as a guide to antibiotic therapy in acute leukaemia. J Clin Pathol 35: 866–869

  10. 10.

    Starke ID, De Beer FC, Donnelly PJ, Catovsky D, Goldman JM, Galton D, Pepys MB (1984) Serum C-reactive protein levels in the management of infection in acute leukaemia. Eur J Cancer Clin Oncol 20: 319–325

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Correspondence to S. O. Lie.

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Grønn, M., Slørdahl, S.H., Skrede, S. et al. C-reactive protein as an indicator of infection in the immunosuppressed child. Eur J Pediatr 145, 18–21 (1986). https://doi.org/10.1007/BF00441846

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Key words

  • Antibiotics
  • Child
  • C-reactive protein
  • Infection
  • Neoplasms