European Journal of Pediatrics

, Volume 148, Issue 1, pp 24–28

Glomerular filtration rate in the preterm infant: the relation to gestational and postnatal age

  • A. J.v. d. Heijden
  • W. F. A. Grose
  • J. J. Ambagtsheer
  • A. P. Provoost
  • E. D. Wolff
  • P. J. J. Sauer
Growth and Development

DOI: 10.1007/BF00441807

Cite this article as:
Heijden, A.J.., Grose, W.F.A., Ambagtsheer, J.J. et al. Eur J Pediatr (1988) 148: 24. doi:10.1007/BF00441807

Abstract

In 41 preterm neonates with a gestational age (GA) varying from 27 to 36 weeks, glomerular filtration rate (GFR) was measured by means of the continuous inulin infusion technique. The reliability of the technique was confirmed. During postnatal development GFR was found to increase in two ways: firstly, an increase with advancing gestational age, associated with the increase in body weight (BW) [GFR (ml/min) =0.15xGA-3.20, r=0.48, P=0.0048]; secondly, a postnatal increase, being independent from increment in BW. An increase in GFR (ml/min·kg) from 0.88±0.23 to 1.18±0.28 was observed between day 4 and day 11 postnatally (P<0.008). This latter increase is probably associated with changes in renal haemodynamics. No significant influence of artificial ventilation on GFR could be demonstrated in preterm neonates.

Key words

Preterm neonate Glomerular filtration rate Development 

Abbreviations

GFR

glomerular filtration rate

BW

body weight

GA

gestational age

PA

postnatal age

Cin

inulin clearance

t1/2

plasma half life

RDS

respiratory distress syndrome

PDA

persistent ductus arteriosus

PROM

premature rupture of membranes

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • A. J.v. d. Heijden
    • 1
  • W. F. A. Grose
    • 2
  • J. J. Ambagtsheer
    • 2
  • A. P. Provoost
    • 3
  • E. D. Wolff
    • 1
  • P. J. J. Sauer
    • 4
  1. 1.Department of Paediatric NephrologyErasmus University and Academic Hospital Rotterdam/Sophia Children's HospitalRotterdamThe Netherlands
  2. 2.Department of Clinical ChemistryErasmus University and Academic Hospital Rotterdam/Sophia Children's HospitalRotterdamThe Netherlands
  3. 3.Department of Paediatric SurgeryErasmus University and Academic Hospital Rotterdam/Sophia Children's HospitalRotterdamThe Netherlands
  4. 4.Department of NeonatologyErasmus University and Academic Hospital Rotterdam/Sophia Children's HospitalRotterdamThe Netherlands

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