European Journal of Pediatrics

, Volume 144, Issue 5, pp 464–466 | Cite as

Defective neutrophil chemotaxis in patients with alpha-1-antitrypsin deficiency

  • A. J. Khan
  • H. E. Evans
  • M. M. Agbayani
Original Investigations
Received:
Accepted:

Abstract

The PMNs of five infants and children with homozygous alpha-1-antitrypsin deficiency (PiZZ phenotype) revealed defective chemotactic migration, and their PiZZ sera generated a higher quantity of chemotactic factor(s).

This defect(s) might have been responsible for the increased incidence of infections found in our deficient PiZZ patients. Further studies are needed to clarify the role of defective chemotaxis in the pathogenesis of chronic lung disease associated with the PiZZ state.

Key words

Chemotaxis Random migration Chemotactic factors Alpha-1-antitrypsin deficiency 

Abbreviations

AAT

alpha-1-antitrypsin

HBS

Hank's balanced salt solution

CI

chemotactic index

RM

random migration

CFI

chemotactic factor inactivator

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • A. J. Khan
    • 1
  • H. E. Evans
    • 1
  • M. M. Agbayani
    • 1
  1. 1.Department of Pediatrics of Interfaith Medical CenterSuny/Downstate Medical CenterBrooklynUSA

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