European Journal of Pediatrics

, Volume 146, Issue 5, pp 468–472 | Cite as

Failure of autoregulation of cerebral blood flow in neonates studied by pulsed Doppler ultrasound of the internal carotid artery

  • G. Jorch
  • N. Jorch
Original Investigations


To reveal the influence of therapeutically induced changes of arterial blood pressure on cerebral circulation, pulsed Doppler measurements of blood velocity in the right internal carotid artery were performed in 23 neonates. A positive correlation between mean arterial blood pressure and time-averaged maximum blood velocity (change more than 0.5%/torr) could be noticed in 16 infants. These infants were supposed to have loss of autoregulation. The main characteristics in this non-autoregulating group were: gestational age <31 weeks, birth weight <1501 g and mean carotid blood velocity <20 cm/s. In accordance with animal experiments we assume that autoregulation does not work below a definite lower limit of brain perfusion, which is reflected by carotid blood velocity in our study. Patients below/equal 1500 g or 30 gestational weeks very often do not exceed this limit and thus do not reach the “range of autoregulation”.

Key words

Cerebral circulation Doppler ultrasonography Autoregulation Neonates 



time mean of the maximum component of velocity profile (area under the curve divided by length of the cycle)


peak systolic velocity


end-diastolic velocity


pulsatility index


transcutaneously measured pCO2


transcutaneously measured pO2


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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • G. Jorch
    • 1
  • N. Jorch
    • 1
  1. 1.UniversitätskinderklinikMünsterGermany

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