Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Hypercalciuria and nephrolithiasis as a presenting sign in Wilson disease


A 9-year-old boy presented with recurrent episodes of renal colic. One year later Wilson disease was diagnosed. Evaluation of liver function and assessment of serum copper, caeruloplasmin concentration and urinary copper excretion in any child presenting with nephrolithiasis is suggested.

This is a preview of subscription content, log in to check access.


  1. 1.

    Leu ML, Strickland GT, Gutaman RA (1970) Renal function in Wilson's disease: response to penicillamine therapy. Am J Med Sci 260:381

  2. 2.

    Litin RB, Randall RV, Goldstein NP, Power MH, Diessner GR (1959) Hypercalciuria in hepatolenticular degeneration (Wilson's disease). Am J Med Sci 238:614–620

  3. 3.

    Silverman A, Roy CC (1983) Wilson's disease in pediatric clinical gastroenterology, 3rd edn. Mosby, St. Louis Toronto London, pp 700–711

  4. 4.

    Warren CBM, Broughton PMB (1962) Wilson disease. Arch Dis Child 37:242–252

  5. 5.

    Wiebers DO, Wilson DM, McLeob RA, Goldstein NP (1979) Renal stones in Wilson's disease. Am J Med 67:250–254

Download references

Author information

Correspondence to E. Azizi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Azizi, E., Eshel, G. & Aladjem, M. Hypercalciuria and nephrolithiasis as a presenting sign in Wilson disease. Eur J Pediatr 148, 548–549 (1989).

Download citation

Key words

  • Hypercalciuria
  • Wilson disease