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Mucopolysaccharidosis II (Hunter disease) with corneal opacities

Report on two patients at the extremes of a wide clinical spectrum

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Abstract

Clinically visible corneal opacities were observed in a patient with an extremely severe form of mucopolysaccharidosis II. In a second patient with an unusually mild form of mucopolysaccharidosis II, discrete corneal opacities were detected by slit-lamp examination. Thus clear corneae can no longer be regarded as a hallmark of mucopolysaccharidosis II.

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References

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Author information

Correspondence to J. Spranger.

Additional information

Supported by grants from the Deutsche Forschungsgemeinschaft and the Stiftung Volkswagenwerk

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Spranger, J., Cantz, M., Gehler, J. et al. Mucopolysaccharidosis II (Hunter disease) with corneal opacities. Eur J Pediatr 129, 11–16 (1978). https://doi.org/10.1007/BF00441369

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Key words

  • Mucopolysaccharidoses
  • Hunter disease
  • Hurler disease
  • Corneal opacities
  • Sulfoiduronate sulfatase deficiency