European Journal of Pediatrics

, Volume 129, Issue 4, pp 267–272 | Cite as

HLA frequencies and haplotypes in children with idiopathic thrombocytopenic purpura (ITP)

  • K.-G. Evers
  • R. Thouet
  • W. Haase
  • J. Krüger
Article

Abstract

26 patients with an acute reversible ITP and 6 with chronic ITP were tissue typed, together with their healthy first-degree relatives. The HLA frequencies of the different groups were compared with those of a normal control population. The only significant difference between the groups was an increase in the frequency of Aw32 in acute ITP patients. HLA-Aw32 was present in 26.9% of patients, but in only 0.8% of the controls (corrected P=0.000027). The possible importance of associations between antigens of the HLA-A locus with certain diseases are discussed. Family analyses and haplotype determinations proved to be unproductive because no familial clustering of ITP was found.

Key words

HLA antigens Idiopathic thrombocytopenic purpura 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Buc, M., Nyulassy, S., Stefanovic, J., Jakubcova, I., Benedekova, M.: HLA-A2 and congenital heart malformations. Tissue Antigens 5, 128 (1975)Google Scholar
  2. Dausset, J., Hors, J.: Some contributions of the HL-A complex to the genetics of human diseases. Transplant. Rev. 22, 44 (1975)Google Scholar
  3. Dausset, J., Degos, L., Hors, J.: The association of the HL-A antigens with diseases. Clin. Immunol. Immunopath. 3, 127 (1974)Google Scholar
  4. Dixon, R. H., Rosse, W. F.: Platelet antibody in autoimmune thrombocytopenia. Brit. J. Haematol. 31, 129 (1975)Google Scholar
  5. Goebel, K. M., Hahn, E., Havemann, K.: HLA matching in autoimmune thrombocytopenic purpura. Brit. J. Haematol. 35, 341 (1977)Google Scholar
  6. Hollander, M., Wolfe, D. A.: Nonparametric statistical methods, p. 115. New York: Wiley and Sons 1973Google Scholar
  7. Hors, J., Griscelli, C., Schmid, M., Dausset, J.: HL-A antigens and immune deficiency states. Brit. Med. J. 1974IV, 45Google Scholar
  8. Karpatkin, S., Siskind, G. W.: In vitro detection of platelet antibody in patients with idiopathic thrombocytopenic purpura and systemic lupus erythematosus. Blood 33, 795 (1969)Google Scholar
  9. Karpatkin, M., Siskind, G. W., Karpatkin, S.: The platelet factor 3 immunoinjury technique re-evaluated: development of a rapid test for antibody: detection in various clinical disorders, including immunologic drug-induced and neonatal thrombocytopenias. J. Lab. Clin. Med. 89, 400 (1977)Google Scholar
  10. Levine, B. B., Stember, R. H., Fotino, M.: Ragweed hayfever: genetic control and linkage to HL-A haplotypes. Science 178, 1201 (1972)Google Scholar
  11. Lurhuma, A. Z., Riccomi, H., Masson, P. L.: The occurrence of circulating immune complexes and viral antigens in idiopathic thrombocytopenic purpura. Clin. exp. Immunol. 28, 49 (1977)Google Scholar
  12. McDevitt, H., Bodmer, W. F.: HL-A, immune-response genes, and disease. Lancet 1974 I, 1269Google Scholar
  13. Myllylä, G., Vaheri, A., Vesikari, T., Penttinen, K.: Interaction between human blood platelets, viruses and antibodies. IV. Post-rubella thrombocytopenic purpura and platelet aggregation by rubella antigen-antibody interaction. Clin. exp. Immunol. 4, 323 (1969)Google Scholar
  14. Shulman, N. R.: A mechanism of cell destruction in individuals sensitized to foreign antigens and its implications in autoimmunity. Ann. intern. Med. 60, 506 (1964)Google Scholar
  15. Simon, M., Bourel, M., Genetet, B., Fauchet, R.: Idiopathic hemochromatosis. Demonstration of recessive transmission and early detection by family HLA typing. New Engl. J. Med. 297, 1017 (1977)Google Scholar
  16. Terasaki, P. J., McClelland, J. D.: Microdroplet assay of human serum cytotoxins. Nature (Lond.) 204, 998 (1964)Google Scholar

Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • K.-G. Evers
    • 1
  • R. Thouet
    • 2
  • W. Haase
    • 2
  • J. Krüger
    • 3
  1. 1.Children's Hospital of the City of CologneCologneGermany
  2. 2.Institute of Numerical StatisticsCologneGermany
  3. 3.Department of Blood Transfusion of the University of CologneGermany

Personalised recommendations