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Study on mammal (rat) of the neuro-muscular synapse function under hyperbaric conditions (11 ata): Effects of the curarization

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Summary

Under hyperbaric conditions (11 ata) obtained with normoxic O2-N2 mixtures spontaneous EMG activity disappears, as do reactions to noise, but this phenomenon is reversible after the substitution of Helium for Nitrogen in the mixture.

Analysis of EMG responses to sciatic nerve excitation has revealed no difference between the EMG tracings recorded under normobaric pressure and those obtained under hyperbaric conditions (O2-N2 or O2-He, 11 ata), and hyperbaric conditions do not seem to interfere with neuro-muscular synaptic transmission. Furthermore, the effect of Pavulon (an antidepolarising, acetyl-cholino-competitive curare-mimetic drug) is similar under normal and hyperbaric conditions: hyperbaria changes neither the onset of neuro-muscular blockage nor its intensity or duration. The absence of a specific effect on synapse function of a change in the diluting gas from nitrogen to helium suggests that there was no change in post-synaptic receptor function. This result is not in accordance with the hypothesis that inert gas pressures of less than 10 ata modify molecular structures particularly at the neuro-muscular synapse level.

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References

  1. Bishop B, Shindell D, Wallis I (1975a) Conduction velocity and neuromuscular transmission of man's ulnar nerve impulses during a simulated dive to 67 feet (3 ata). In: Lanphier EH, Rahn H (eds) Mar. Water-pressure, vol II. Stat University of NY at Buffalo, Buffalo NY, pp 117–119

  2. Bishop B, Hoffman H, Wallis I, Shindell D (1975b) Effects of increased ambient pressure and nitrogen on man's monosynaptic reflexes. J Appl Physiol 38: 86–90

  3. Charmasson R (1973) Approche moléculaire des troubles nerveux observés dans les caissons. Perspectives pour la plongée profonde. Rapport Contrat DRME 73/860

  4. Charmasson R, Sicardi F (1972) Modification des propriétés physico-chimiques des biopolymères sanguins en hyperbarie gazeuse. CR Acad Sci [D] (Paris) 275: 1637–1640

  5. Charmasson R, Sieardi F, Catella R (1972) Etude par la technique osmométrique de l'action sur le sang humain de la presssion et des gaz comprimés dissous. CR Acad Sci [D] (Paris) 275: 1779–1782

  6. Friess SL, Durant RC, Martin HL, Cowan MJ (1970) Toxic effects induced in neuromuscular tissues by work in hyperbaric He/O2/CO2 environments. Toxicol Appl Pharmacol 17: 443–461

  7. Friess SL, Durant RC, Hudak WV, Boyer RD (1975) Effects of moderate pressure He-O2 saturation and response modifiers on neuromuscular function. Undersea Biomed Res 2: 35–41

  8. Friess SL, Jefferson TA, Durant RC (1971) Viability of neuromuscular tissue in hyperbaric gaseous environments containing variable N2-He content ratios. Toxicol Appl Pharmacol 20: 1–13

  9. Zaltsman GL (1968) The initial manifestations of helium narcosis in man. In: Zaltsman GL (ed) Giperbariyevaya epilepsiya y narkoz. Isadtel' stvo Nauka, Leningrad, pp 163–168

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Barthélémy, L., Belaud, A. Study on mammal (rat) of the neuro-muscular synapse function under hyperbaric conditions (11 ata): Effects of the curarization. Europ. J. Appl. Physiol. 49, 349–358 (1982). https://doi.org/10.1007/BF00441296

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Key words

  • Curare-mimetic drugs
  • Inert gas narcosis
  • Neuro-muscular synapse