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Normoprolactinemia in boys with marked gynecomastia

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Abstract

Pubertal gynecomastia normally occurs as a transient phenomenon of several months duration, whereas marked pubertal gynecomastia (more than 6 cm in diameter) may persist into aduldhood. In the present study the possible involvement of prolactin (PRL) secretion in the development of marked pubertal gynecomastia was investigated. The diurnal variations of PRL, luteinizing hormone (LH), follicle-stimulating hormone (FSH), as well as the basal values of testosterone (T) and estradiol (E2) were determined in 5 pubertal boys with marked gynecomastia and in 5 age-matched controls. Mean age of all patients was 14.4 years. The pubertal development was classified as P 3–4.

In comparison to controls, boys with marked gynecomastia revealed no differences in basal values of PRL, LH and FSH, as well as in peak values of all hormones during sleep. The response of PRL, LH and FSH to LHRH/TRH stimulation was normal for pubertal age in both groups. In comparison to controls, decreased mean plasma T levels (P<0.05) and slightly increased E2 levels (P<0.05) were found in boys with marked gynecomastia. The E2/T ratio was also higher in boys with gynecomastia (P<0.005).

These data suggest that prolactin, a hormone which may be increased in galactorrhea, is not involved in the development of marked pubertal gynecomastia in boys. The above findings suggest that slightly elevated day-time E2 levels may be involved in the development of female-appearing breasts in pubertal boys.

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References

  1. 1.

    Hamer DB (1975) Gynecomastia. Br J Surg 62:326–329

  2. 2.

    Nydick M, Bustos J, Dale JH Jr, Chester P, Rawson RW (1961) Gynecomastia in adolescent boys. JAMA 178:449–454

  3. 3.

    Lee PA (1975) The relationship of concentration of serum hormones to pubertal gynecomastia. J Pediatrics 86:212–215

  4. 4.

    La Franchi SH, Parlow AF, Lippe BM, Coyotupa J, Kaplan SA (1975) Pubertal gynecomastia and transient elevation of serum estradiol level. Am J Dis Child 129:927–931

  5. 5.

    Tanner JM (1962) Growth at adolescence. Blackwell, Oxford, pp 28–39

  6. 6.

    Ehara Y, Yen SSC, Siler TM (1975) Serum prolactin levels during puberty. Am J Obstet Gynecol 117:995–997

  7. 7.

    Beck W, Wuttke W (1980) Diurnal variations of plasma LH, FSH and prolactin in boys and girls from birth to puberty. J Clin Endocrinol Metab 50:635–639

  8. 8.

    Bidlingmaier F, Wagner-Barnack M, Butenandt O, Knorr D (1973) Plasma estrogens in childhood and puberty under physiologic and pathologic conditions. Pediat Res 7:901–907

  9. 9.

    Large DM, Anderson DC, Laing I (1980) Twenty-four hour profiles of serum prolactin during male puberty with and without gynecomastia. Clin Endocrinol 12:293–302

  10. 10.

    Faulborn KW, Fenske M, Pitzel L, König A (1979) Effects of an intravenous injection of tetracosactid on plasma corticosteroid and testosterone levels in unstressed male rabbits. Acta Endocrinologica 91:511–518

  11. 11.

    Turkington RW (1972) Serum prolactin levels in patients with gynecomastia. J Clin Endocrinol 34:62–66

  12. 12.

    Marynick SP, Nisula BC, Pita JC Jr, Loriaux DI (1980) Persistent pubertal macromastia. J Clin Endocrinol Metab 50:128–130

  13. 13.

    Large DM, Anderson DC (1979) Twenty-four hour profiles of circulating androgens and oestrogens in male puberty with and without gynecomastia. Clin Endocrinol 11:505–521

  14. 14.

    Chaussain JL, Roger M, Brijani A, Georges P, Job JC (1978) Endocrine studies in boys with pubertal gynecomastia. Pediat Res 12:1086

  15. 15.

    Latorre H, Kenny FM (1973) Idiopathic gynecomastia in seven preadolescent boys. Am J Dis Child 126:771–773

  16. 16.

    Buckman MT, Maclean C, Peake GT, Rhodes JMd, Srivastava LS (1980) Absence of prolactin hypersecretion during sleep in men with gynecomastia. Horm Metab Res 12:344–345

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Beck, W. Normoprolactinemia in boys with marked gynecomastia. Eur J Pediatr 137, 41–44 (1981). https://doi.org/10.1007/BF00441168

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Key words

  • Gynecomastia
  • Prolactin
  • Gonadotropins
  • Steroids