European Journal of Nuclear Medicine

, Volume 11, Issue 1, pp 43–45 | Cite as

Intracranial meningioma with abnormal localization of bone-seeking radiopharmaceutical: Correlation with gross and microscopic pathology

  • Wei-Jen Shih
  • Ay-Ming Wang
  • Peggy A. Domstad
  • Shoa-Ru Cho
  • Frank H. DeLand
Case Reports
Received:

Abstract

Meningioma is one of the neoplasms in which there may be extraosseous localization of bone-seeking radiopharmaceuticals. Tumor calcification, calvarial erosion, and the formation of reactive bone have been proposed as the cause of this abnormal tracer localization. We present a patient with a frontal meningioma that was evaluated using 99mTc-methylene-diphosphonate bone scintigraphy, head computed tomography, and skull radiography; the homogeneous density seen in the radiographic studies corresponded to the area of bone-seeking-agent localization shown in the scitigram. At autopsy, bony tissue and a few psammoma bodies were found in the meningioma, and apparently accounted for the bone-tracer localization. There was no calvarial erosion and no formation of reactive bone. If skull-radiographic studies show a homogeneous, radio-opaque lesion with no reactive changes in the adjacent skull, a meningioma showing a localization of a bone-seeking radiopharmaceutical may be predicted to have bonetissue formation with or without psammoma bodies.

Key words

Meningioma bone-seeding radiopharmaceutical Tc-99m MDP extra oseous localization tumor calcification psammoma body bony spicule 
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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • Wei-Jen Shih
    • 4
    • 1
  • Ay-Ming Wang
    • 2
  • Peggy A. Domstad
    • 4
    • 1
  • Shoa-Ru Cho
    • 3
  • Frank H. DeLand
    • 4
  1. 1.University of Kentucky Medical CenterLexingtonUSA
  2. 2.Department of RadiologyBrigham and Women's HospitalBostonUSA
  3. 3.Department of RadiologyMedical College of VirginiaRichmondUSA
  4. 4.Nuclear Medicine Service (115CDD)VA Medical CenterLexingtonUSA

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