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Psychopharmacology

, Volume 81, Issue 1, pp 24–27 | Cite as

Cholinergic-dopaminergic interactions in experimental catalepsy

  • W. R. Klemm
Original Investigations

Abstract

The ‘pinch-induced’ model of catalepsy in the mouse was disrupted by atropine sulfate (4 mg/kg IP), confirming an earlier finding, and also by the antinicotinic mecamylamine (4 mg/kg). Either anticholinergic, when given concurrently with haloperidol (5 mg/kg), interfered with the typical haloperidol-induced enhancement of catalepsy. In mice pretreated with a peripheral cholinergic blocker, the cholinomimetic pilocarpine (10 mg/kg) enhanced catalepsy. The dopamine (DA) agonist apomorphine (5 mg/kg) reversed the enhancement that was normally caused by pilocarpine. Apomorphine did not stimulate open field locomotion in mice that were pretreated with pilocarpine. This lack of correlation between catalepsy and open field activity indicates that catalepsy in a unique state that involves more than mere absence of movement. The DA mechanisms, thus, appear to be specifically antagonistic to catalepsy or, conversely, cholinergic mediation of catalepsy involves reduced influence of DA systems.

Key words

Catalepsy Acetylcholine Dopamine Pilocarpine Apomorphine Haloperidol Atropine Mecamylamine Muscarinic Nicotinic 

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Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • W. R. Klemm
    • 1
  1. 1.Department of Veterinary AnatomyTexas A & M UniversityCollege StationUSA

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