, Volume 136, Issue 3, pp 119–123 | Cite as

Phospholipase activity in Cryptococcus neoformans

  • V. VidottoEmail author
  • A. Sinicco
  • D. Di Fraia
  • S. Cardaropoli
  • S. Aoki
  • S. Ito-Kuwa
Human and Animal Mycology


Phospholipases have only been detected in a few fungi and yeasts, in particular in Candida albicans. Secreted phospholipases are considered by some researchers to be a potential factor of virulence and pathogenicity in C. albicans. Twenty-three Cryptococcus neoformans strains were tested in order to observe phospholipase production. Twenty-two of the 23 strains tested were able to produce phospholipases, and the ratio diameter of the colony to total diameter of the colony plus zone of precipitation (Pz) ranged between 0.271 and 0.949. C. neoformans, just like C. albicans, can be divided on the basis of the Pz into different strains according to their virulence and pathogenicity. There also appeared to be a correlation between the phospholipase production and the size of the capsule in the strains isolated from AIDS patients. For this reason, further studies on C. neoformans phospholipase activity would be useful in evaluating the virulence of different strains.

Key words

Cryptococcus neoformans phospolipase virulence AIDS 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • V. Vidotto
    • 1
    Email author
  • A. Sinicco
    • 1
  • D. Di Fraia
    • 1
  • S. Cardaropoli
    • 1
  • S. Aoki
    • 2
  • S. Ito-Kuwa
    • 2
  1. 1.Laboratorio Micologia MedicaDipartimento discipline Medico-Chirurgiche Università di Torino, Sez. Malattie InfettiveTorinoItaly
  2. 2.General Research InstituteNippon Dental UniversityNiigataJapan

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