Experimental candidiasis associated with liver injury
- 16 Downloads
In an attempt to perform a further investigation on the proposal that an increasing susceptibility to Candida infection in liver injury may be related to unsaturated transferin level (UIBC) and/or to a total amount of transferrin represented by TIBC, we conducted experimental candidiasis using mice with galactosamine-induced liver injury and investigated the effect of preadministration of transferrin prior to inoculation of Candida albicans. Final mortality was 10% in the mice without liver injury and without transferrin (Group 1) and ones with liver injury and with transferrin (Group 3). By contrast a 50% mortality was given in ones only with liver injury (Group 2). The TIBCs in Groups 1 and 3 were significantly higher than that in Group 2. The UIBCs in Groups 2 and 3, although there was no significant difference between them, were significantly lower than that in Group 1. This study confirmed that transferrin (TIBC) may have a direct deterring effect on systemic Candida infection and the decreased TIBC in the liver injury enhances the growth of C. albicans.
Key wordsliver injury D-galactosamine candidiasis transferrin iron
Unable to display preview. Download preview PDF.
- 1.Abe F, Tateyama M, Shibuya H, Azumi N, Ommura Y. Experimental candidiasis in iron overload. Mycopathologia 1985; 89:59–63.Google Scholar
- 2.Abe F, Nagata S, Hotchi M. Experimental candidiasis in liver injury. Mycopathologia 1987; 100:37–42.Google Scholar
- 3.Artis WM, Patrusky E, Rastinejad F, Duncan RL Jr. Fungistatic mechanism of human transferrin for Rhizopus oryzae and Trichophyton mentagrophytes: alternative to simple iron deprivation. Infect Immun 1983; 41:1269–78.Google Scholar
- 4.Bezkorovainy A. Antimicrobial properties of iron-binding proteins. Adv Exp Med Biol 1981; 135:139–54.Google Scholar
- 5.Keppler D, Lesch R, Reutter W, Decker K. Experimental. hepatitis induced by D-galactosamine. Exp Mol Pathol 1968; 9:279–90.Google Scholar
- 6.Larcher VF, Wyke RJ, Mowat AP, Williams R. Bacterial and fungal infection in children with fulminant hepatic failure: possible role of opsonisation and complement deficiency. Gut 1982; 23:1037–43.Google Scholar
- 7.Okudaira M. Pathology of opportunistic fungus infection. Tr Soc Pathol Jpn (in Japanese) 1985; 74:61–91.Google Scholar
- 8.Petro TM, Bhattacharjee JK. Effect of dietary essential amino acid limitations upon the susceptibility to Salmonella typhimurium and the effect upon humoral and cellular immune responses in mice. Infect Immun 1981; 32:251–59.Google Scholar
- 9.Shiraishi A, Arai T. Antifungal activity of transferrin. Sabouraudia 1979; 17:79–83.Google Scholar
- 10.Walsh TJ, Hamilton SR. Disseminated aspergillosis complicating hepatic failure. Arch Intern Med 1983; 143:1189–91.Google Scholar
- 11.Weinberg ED. Iron withholding: a defence against infection and neoplasia. Physiol Rev 1984; 64:65–102.Google Scholar