, Volume 104, Issue 1, pp 3–6 | Cite as

Experimental candidiasis associated with liver injury

Role of transferrin
  • Fumihiko Abe
  • Tadashi Katoh
  • Hayashi Inaba
  • Masao Hotchi


In an attempt to perform a further investigation on the proposal that an increasing susceptibility to Candida infection in liver injury may be related to unsaturated transferin level (UIBC) and/or to a total amount of transferrin represented by TIBC, we conducted experimental candidiasis using mice with galactosamine-induced liver injury and investigated the effect of preadministration of transferrin prior to inoculation of Candida albicans. Final mortality was 10% in the mice without liver injury and without transferrin (Group 1) and ones with liver injury and with transferrin (Group 3). By contrast a 50% mortality was given in ones only with liver injury (Group 2). The TIBCs in Groups 1 and 3 were significantly higher than that in Group 2. The UIBCs in Groups 2 and 3, although there was no significant difference between them, were significantly lower than that in Group 1. This study confirmed that transferrin (TIBC) may have a direct deterring effect on systemic Candida infection and the decreased TIBC in the liver injury enhances the growth of C. albicans.

Key words

liver injury D-galactosamine candidiasis transferrin iron 


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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Fumihiko Abe
    • 1
  • Tadashi Katoh
    • 1
  • Hayashi Inaba
    • 1
  • Masao Hotchi
    • 1
  1. 1.Department of PathologyShinshu University School of MedicineMatsumotoJapan

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